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Source: SARS-CoV-2 Cancers  Mar 05, 2022  7 months ago
Post COVID-19 Individuals Advised To Take Probiotics As Study Shows SARS-CoV-2 Induced Gut Microbiome Dysbiosis Increases Risk For Colorectal Cancer!
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Post COVID-19 Individuals Advised To Take Probiotics As Study Shows SARS-CoV-2 Induced Gut Microbiome Dysbiosis Increases Risk For Colorectal Cancer!
Source: SARS-CoV-2 Cancers  Mar 05, 2022  7 months ago
SARS-CoV-2 Cancers: Typically, most viral infections have the potential of increasing the risk of cancer but the occurrences of cancerous tissues and tumors normally happens over a long period of time post infection such as in the case of HPV infections etc.


 
However, based on numerous physicians reports and emerging observations, SARS-CoV-2 infections have the ability of causing either existing cancers to progress much faster or the emergence of accelerated aggressive cancers!
 
The reason for these is that the SARS-CoV-2 virus is able to cause immunodeficiency conditions by affecting the various components and immune cells of the immune system plus it also cases the downregulation of certain cancer protective genes and proteins coupled with the fact that it also affects various cellular pathways that lead to the process of oncogenesis not forgetting that it also causes tissue damage and long term low grade inflammation, both of which are factors that causes cancers.
https://www.thailandmedical.news/news/why-is-no-one-warning-the-masses-that-the-sars-cov-2-spike-proteins-are-causing-major-immunodeficiency-issues-in-all-infected-individuals
 
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8206711/
 
https://www.thailandmedical.news/news/millions-of-recovered-individuals-who-had-mild-or-asymptomatic-sars-cov-2-infection-are-unaware-they-have-prolonged-immune-activation-and-systemic-inf
 
Already numerous studies are merging about the correlation between various cancers and SARS-CoV-2 infections.
https://www.thailandmedical.news/news/breaking-new-international-study-warns-that-sars-cov-2-infections-will-lead-to-cancers-especially-colorectal-cancers-due-to-disruption-in-autophagy
 
https://www.thailandmedical.news/news/can-sars-cov-2-especially-the-omicron-variant-cause-hpv-and-oncogenic-hpv-reactivation-urgent-studies-warranted-based-on-growing-incidences
 
https://www.thailandmedical.news/news/breaking-sars-cov-2-infection-induces-increase-of-gp73-that-causes-dysglycaemia-increased-gp73-could-also-imply-future-liver-disease-and-liver-cancer
 
-millions-expected-to-get-cancer-eventually">https://www.thailandmedical.news/news/breaking-news-chinese-researchers-discover-circrnas-encoded-by-sars-cov-2-virus-that-can-cause-cancer-millions-expected-to-get-cancer-eventually
 
https://www.thailandmedical.news/news/breaking-research-reveals-that-tmprss2,-an-endothelial-cell-surface-protein-that-is-involved-in-sars-cov-2-cell-entry,-is-also-a-tumor-suppressor

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A new SARS-CoV-2 Cancers study by researchers from Morsani College of Medicine, University of South Florida-USA and James A. Haley Veterans Hospital, Florida-USA has found that SARS-CoV-2 induced gut microbiome dysbiosis can increase the risk for colorectal cancer!
 
In fact, it is anticipated that the besides liver, lung, testicular, throat and brain cancers, colorectal cancers will also rise exponentially in coming months and years, all due to SARS-CoV-2 infections which affects more than a few ways in causing these cancers.
 
In the case of colorectal cancers, as the SARS-CoV-2 virus targets the epithelial cells of the gastrointestinal linings and also cause autophagy disruptions, and now also causes microbiome dysbiosis besides affecting other oncogenic pathways, the risk of developing such a cancer is even going to be much higher in many.
 
To date, the emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in December 2019 led to a worldwide pandemic with over 443 million confirmed infections and over 5.99 million deaths.
 
Early studies have shown higher mortality rates from SARS-CoV-2 infection in cancer patients than individuals without cancer.
 
The study team from University of South Florida reviewed the evidence that the gut microbiota plays a crucial role in health and has been linked to the development of colorectal cancer (CRC). Investigations have shown that SARS-CoV-2 infection causes changes to the gut microbiota, including an overall decline in microbial diversity, enrichment of opportunistic pathogens such as Fusobacterium nucleatum bacteremia, and depletion of beneficial commensals, such as the butyrate-producing bacteria.
 
It was found that these changes lead to increased colonic inflammation, which leads to gut barrier disruption, expression of genes governing CRC tumorigenesis, and tumor immunosuppression, thus further exacerbating CRC progression.
 
Additionally, a long-lasting impact of SARS-CoV-2 on gut dysbiosis might result in a greater possibility of new CRC diagnosis or aggravating the condition in those already afflicted.
 
The study findings show how infection with SARS-CoV-2 impacts the gut microbiota and the effects this will have on CRC carcinogenesis and progression.
 
The study findings were published in the peer reviewed journal: Cancers. https://www.mdpi.com/2072-6694/13/11/2676/htm
 
The gut microbiota plays a crucial role in health and has been linked to CRC development. https://www.nature.com/articles/nrmicro3344

Schematic showing changes in the gut microbiome caused by SARS-CoV-2 infection, their correlation with COVID-19 severity, and the biological consequences of these changes.

Early investigations have shown that the gut microbiota and mycobiota are significantly altered in patients with COVID-19. Changes to the gut microbiota caused by SARS-CoV-2 infection include enrichment of opportunistic pathogens and depletion of beneficial commensals, an overall decline in microbial diversity, a loss of butyrate-producing bacteria, and F. nucleatum bacteremia.
 
In both CRC and SARS-CoV-2 infection, the increased expression of genes involved in the inflammatory response leads to a worsening in gut barrier dysfunction. Changes caused by SARS-CoV-2 infection may further exacerbate CRC progression through increased expression of CRC tumorigenesis markers, tumor immunosuppression, and the induction of inflammation, leading to gut barrier disruption and worsening CRC progression.
 
Lead author, Dr Mark C. Howell from the Department of Internal Medicine, Morsani College of Medicine, University of South Florida commented, “A complete understanding of the complex factors leading to dysbiosis has not yet materialized. It is critically important that we understand how infection with SARS-CoV-2 will impact the gut microbiota and CRC progression. The impact of SARS-CoV-2 on gut dysbiosis and the gut microbiota may be long-lasting, thus underscoring the importance of restoring a competent microbiome to resist the development of GI diseases, such as irritable bowel syndrome, allergic colitis, recurrent Clostridioides difficile infection, and CRC.
 
One of the ways that Post-COVID-19 individuals can reduce their risk of colorectal cancer is to introduce dietary changes which involves no processed foods, no meats, no fats, no sugars but rather diets rich with fibers, vegetable and fruits. Probiotics are also useful in helping to colonize the gut with the right kinds of microbiome.

Please help support this website by making a generous donation not only for the sustainability of the website but also for all our research and community initiatives. We are not funded by any entities and really need help. Your help not only saves lives directly but also indirectly. 
https://www.thailandmedical.news/p/sponsorship


For more on SARS-CoV-2 Cancers, keep on logging to Thailand Medical News.
 
 
 

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