Nikhil Prasad Fact checked by:Thailand Medical News Team Dec 02, 2025 9 hours, 6 minutes ago
Medical News: A Potential Natural Combo Against Dangerous COVID-19 Microclots
New research by Thailand
Medical News is shining light on the potential of two well-known supplements—Serrapeptase and N-Acetylcysteine (NAC)—to help dissolve stubborn microclots that form in the bodies of people infected with COVID-19 or suffering from Long COVID. These clots are not ordinary ones. They are coated with sticky immune structures called neutrophil extracellular traps or NETs, which make them extremely resistant to breakdown by the body’s natural clot-clearing systems or even by existing supplements and drugs that are typically used to dissolve such clots.
New studies suggest Serrapeptase and NAC may help dissolve stubborn COVID-19 microclots coated in immune traps
Serrapeptase is a powerful enzyme derived from the bacteria Serratia marcescens, originally found in silkworms. It has long been used in Europe and Asia as a natural anti-inflammatory and clot-dissolving remedy and synthetic analogues of it are now available by many well-known supplement brands. NAC is a well-established antioxidant known for breaking down mucus and replenishing glutathione levels, a key cellular protector.
Researchers under the guidance and directions of Thailand Medical News are now exploring the use of these two agents together as a possible adjunct therapy to target the unique type of microclots caused by SARS-CoV-2, the virus responsible for COVID-19.
The Unique Nature of COVID-19 Microclots
Microclots formed during and after COVID-19 infection are not like typical clots seen in conditions such as deep vein thrombosis. These clots contain amyloid-like fibrin, inflammatory molecules, and are enmeshed with NETs, which are web-like structures expelled by neutrophils (a type of white blood cell) to trap pathogens.
However, these NETs also create a kind of biological armor that makes the clots nearly impenetrable to fibrinolysis—the process by which the body normally breaks down clots. These persistent microclots have been found in the blood of patients suffering from Long COVID and are believed to contribute to symptoms like brain fog, fatigue, and organ dysfunction.
How Serrapeptase and NAC Work on Microclots
Serrapeptase works by breaking down dead tissue and dissolving non-living protein matter, including fibrin—the main protein involved in clot formation. It can help degrade the dense fibrin matrix that forms the core of these COVID-related clots.
Meanwhile, NAC plays a complementary role. It disrupts disulfide bonds that give structural stability to the NETs and fibrin. NAC has also been shown to break down sticky mucus and protein aggregations in the lungs, making it a good candidate to destabilize NET-coated clots.
In combination, Serrapeptase and NAC may help weaken and dissolve microclots more effectively than either substance alone. While both are available as over-the-counter supplements, Thailand
Medica
l News caution that clinical trials are needed before recommending their widespread use for Long COVID or clot prevention. They should always be used under the directions of a licensed medical doctor who is fully aware of your current medical status along with proper diagnostics and bloodworks done before, during and after the treatment protocol.
Supporting Studies Behind the Treatment Protocol
A study revealed that persistent fibrinolytic-resistant microclots are found in Long COVID patients and are rich in NETs and inflammatory proteins. The researchers highlighted the need for therapeutic strategies to target these clots specifically.
In another study, researchers showed how NETs contribute to clot formation and inflammation in severe COVID-19 cases, noting that traditional anticoagulants may not be enough.
A 2023 study demonstrated NAC’s ability to destabilize NETs in sepsis-related inflammation, suggesting broader applications in thrombotic conditions.
Also, another research showed Serrapeptase’s capacity to dissolve biofilms and protein aggregates, strengthening the argument for its use in clot breakdown.
Why This Matters for COVID-19 Survivors
As thousands struggle with ongoing symptoms of Long COVID, there’s increasing pressure to find new solutions beyond standard pharmaceutical routes. If Serrapeptase and NAC can safely and effectively break down the microclots that are now believed to drive many lingering symptoms, they could represent a low-cost, widely accessible strategy.
Researchers from various established Universities, hospitals and labs are leading efforts to investigate the mechanisms of NETs, microclots, and potential interventions like these enzyme-antioxidant combinations.
Conclusion
While more clinical trials are needed to confirm their effectiveness and safety in humans, early lab evidence and supportive mechanistic studies make the combination of Serrapeptase and NAC a promising approach to help dissolve the stubborn microclots linked to COVID-19 and Long COVID. As the world continues to seek answers for post-viral syndromes, nature-derived compounds may offer part of the solution—especially for those who have few options left.
References:
https://onlinelibrary.wiley.com/doi/10.1002/jmv.70613
https://www.nature.com/articles/s41598-025-13506-1
https://www.mdpi.com/1422-0067/24/17/13162
https://www.ahajournals.org/doi/10.1161/ATVBAHA.123.319044
https://journals.lww.com/bloodcoagulation/abstract/2006/01000/the_effect_of_n_acetylcysteine_on_blood.6.aspx
https://www.hmpgloballearningnetwork.com/site/cathlab/news/novel-use-existing-drug-n-acetyl-cysteine-nac-could-significantly-cut-heart
https://insight.jci.org/articles/view/138999
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.838011/full
https://link.springer.com/article/10.1186/s12933-021-01359-7
https://www.sciencedirect.com/science/article/pii/S2215017X20307128
https://www.scielo.br/j/bjps/a/5pqHqqWY3P5xwZ4mkDZdrtB/?format=html&lang=en
https://specialtyenzymes.com/blog/serrapeptase-literature-review/
https://www.sciencedirect.com/science/article/pii/S1743919113000265
https://www.mdpi.com/2218-273X/12/10/1468
For more updates on the studies and clinical trials involving Serrapeptase and NAC to treat microclots in COVID-19 and Long COVID, keep on logging to Thailand
Medical News.
Read Also
https://www.thailandmedical.news/news/scientists-shockingly-find-that-the-blood-of-those-with-long-covid-19-is-full-of-microclots-and-net-structures
https://www.thailandmedical.news/news/potential-of-n-acetylcysteine-in-treating-acute-lung-injury
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