Study Shows That Females With Single Dose Of HPV Vaccine Obtain Similar Protection As Multiple Doses
A recent study revealed that one dose of the HPV vaccine
may prevent infection from the potential cancer
-causing virus, according to research published in JAMA Network Open
from The University of Texas Health Science Center at Houston (UTHealth).
More than 34,800 new cancer
diagnoses are linked to human papillomavirus
) annually just in America alone according to the Centers for Disease Control (CDC). The virus is thought to account for more than 90% of all cervical and anal cancers
, more than 60% of all penile cancers
, and approximately 70% of all oral cancers.
Though results of the paper showed that a single dose may be as effective as the currently recommended two- or three-dose series, it's too early for people to rely on a single dose of the vaccine
for protection, according to senior author Dr Ashish A. Deshmukh, Ph.D., MPH, an Assistant Professor at UTHealth School of Public Health.
Dr Deshmukh told Thailand Medical
News, "HPV vaccine
coverage is less than 10% globally because of poor vaccine
uptake rates in many resource-limited countries. Ensuring boys and girls receive their first dose is a big challenge in several countries and a majority of adolescents are not able to complete the recommended series due to a lack of intensive infrastructure needed to administer two or three doses. If ongoing clinical trials provide evidence regarding sustained benefits of a one-dose regimen, then implications of single-dose strategy could be substantial for reducing the burden of these cancers
Though the study participants included only women, the CDC recommends a two-dose regimen for all children starting the series before age 15 or a three-dose regimen if the series is started between ages 16 to 26. The latest generation of HPV vaccine
can protect against nearly 90% of cancer
infections. Yet, current vaccinations rates are less than ideal, half of people in the U.S. are not vaccinated against this common sexually transmitted infection.
Lead author Dr Kalyani Sonawane, Ph.D., who is an Assistant Professor at UTHealth School of Public Health commented, "The current HPV vaccine
dosing regimen can be cumbersome for people to understand. If one dose is proven effective in trials, the vaccine regimen will be simplified. This will help improve the coverage rate among adolescents that are currently below the Healthy People 2020 goal and possibly will also increase the momentum of uptake in the newly approved age group."
Reference : Kalyani Sonawane et al. Prevalence of Human Papillomavirus Infection by Number of Vaccine Doses Among US Women.&a
mp;nbsp;JAMA Network Open 2019;2(12):e1918571. DOI: 10.1001/jamanetworkopen.2019.18571