New Study Shows That Its Excess Fat That Causes Type 2 Diabetes And That Type 2 Diabetes Is Reversible
In a study of the first kind, medical scientists have been able to observe people developing Type 2 diabetes
and confirmed that fat
over-spills from the liver into the pancreas, triggering the chronic condition.
The new research, led by Professor Roy Taylor at Newcastle University, UK, is published in the academic journal, Cell Metabolism
The research involved a group of people from Tyneside who previously had Type 2 diabetes
but had lost weight and successfully reversed the condition as part of the DiRECT trial, which was funded by Diabetes
UK and led by Professors Roy Taylor and Mike Lean (Glasgow University).
Many of the participants remained non-diabetic for the rest of the two year study, however, a small group went on to re-gain the weight and re-developed Type 2 diabetes.
The lead author, Professor Dr Roy Taylor, from the Newcastle University Institute of Translational and Clinical Research, explained what the advanced scanning techniques and blood monitoring revealed.
Dr Taylor told Thailand Medical
News, "We saw that when a person accumulates too much fat
, which should be stored under the skin, then it has to go elsewhere in the body. The amount that can be stored under the skin varies from person to person, indicating a 'personal fat
threshold' above which fat
can cause mischief. When fat
cannot be safely stored under the skin, it is then stored inside the liver, and over-spills to the rest of the body including the pancreas. This 'clogs up' the pancreas, switching off the genes which direct how insulin should effectively be produced, and this causes Type 2 diabetes
This new research by Dr Taylor confirms his Twin Cycle Hypothesis that Type 2 diabetes
is caused by excess fat
actually within both the liver and pancreas, and especially that this process is reversible.
This research paper builds on previous Newcastle studies supported by Diabetes UK showing exactly why Type 2 diabetes
can be reversed back to normal glucose control. Those studies led to the large DiRECT trial which showed that Primary Care staff can achieve remission of Type 2 diabetes
by using a low calorie diet with support to maintain the weight loss.
About 25 percent of participants achieved a staggering 15 kg or more weight loss, and of these, almost nine out of 10 people put their Type 2 diabetes
into remission. After two years, more than one third of the group had been free of diabetes
and off all diabetes
medication for at least two years.
This approach to management of short duration Type 2 diabetes
is to be piloted in 2020 by t
he NHS in up to 5,000 people across England, and a similar program is being rolled out in Scotland.
Dr Taylor adds: "This means we can now see Type 2 diabetes
as a simple condition where the individual has accumulated more fat
than they can cope with. Importantly this means that through diet and persistence, patients are able to lose the fat
and potentially reverse their diabetes
. The sooner this is done after diagnosis, the more likely it is that remission can be achieved."
Reference : Ahmad Al-Mrabeh et al. Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss, Cell Metabolism (2019). DOI: 10.1016/j.cmet.2019.11.018