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Source: COVID-19 Warnings  Sep 10, 2020  20 days ago
COVID-19 Warnings: Chinese Study Shows That More Cats Might Have Contracted COVID-19 Than Thought
COVID-19 Warnings: Chinese Study Shows That More Cats Might Have Contracted COVID-19 Than Thought
Source: COVID-19 Warnings  Sep 10, 2020  20 days ago
COVID-19 Warnings: Researchers from Huazhong Agricultural University-China  led By Dr Meilin Jin, a Professor from the Department of Agricultural Microbiology have in a new study that was based in Wuhan have discovered that more cats might be contracting the SARS-CoV-2 coronavirus  than first believed.


 
The study also shows that cats are fighting off the virus with naturally developed antibodies but they too could be at risk of reinfection.
 
The study findings were published in the peer-reviewed journal: Emerging Microbes & Infections. https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1817796?scroll=top&needAccess=true
 
The study team in the Chinese city of Wuhan took blood samples from 102 cats between January and March 2020, following the first outbreak. Nasal and anal swabs were also collected.
 
The team found COVID-19 antibodies present in 15 of the blood samples taken from the cats. Of these, 11 cats had neutralizing antibodies ie proteins that bind so successfully to the novel coronavirus they block the infection.
 
However none of the cats actually tested positive for COVID-19 or displayed obvious symptoms and, according to the results of return visits, none of these felines have died.
 
The study sample of cats looked at included 46 abandoned from 3 animal shelters, 41 from 5 pet hospitals, and 15 cats were from COVID-19 patient families.
 
Interestingly the three cats with the highest levels of antibodies were all owned by patients who had been diagnosed with COVID-19, whilst there were also signs of cats being infected with the virus by other cats from those that were abandoned (4) or based in the pet hospitals (4).
 
Lead author Professor Meilin Jin commenting on the findings states that whilst there is currently no evidence for cat-to-human transmission, precautions should always be considered.
 
She said, “Though the infection in stray cats could not be fully understood, it is reasonable to speculate that these infections are probably due to the contact with SARS-CoV-2 polluted environment, or COVID-19 patients who fed the cats. Therefore measures should be considered to maintain a suitable distance between COVID-19 patients and companion animals such as cats and dogs, and hygiene and quarantine measures should also be established for those high-risk animals.”
 
 A cohort of serum samples were collected from cats in Wuhan, including 102 sampled after COVID-19 outbreak, and 39 prior to the outbreak. Fifteen sera collected after the outbreak were positive for the receptor binding domain (RBD) of SARS-CoV-2 by indirect enzyme linked immunosorbent assay (ELISA).
 
Among them, 11 had SARS-CoV-2 neutralizing antibodies with a titer ranging from 1/20 to 1/1080. No serological cross-reactivity was detected between the SARS-CoV-2 and type I or II feline infectious peritonitis virus (FIPV).
 
 In addition, the study team continuously monitored the serum antibody dynamics of two positive cats every 10 days over 130 days. Their serum an tibodies reached the peak at 10 days after first sampling, and declined to the limit of detection within 110 days. The study data demonstrated that SARS-CoV-2 has infected cats in Wuhan during the outbreak and provided serum antibody dynamics in cats, providing an important reference for the clinical treatment and prevention of COVID-19.
 
The study team assessed the type of antibody reactions in thorough detail and were able to describe the dynamic characteristics of the antibodies found.
 
Significantly amongst many discoveries within the antibodies, they saw that the type of reaction produced by the cats resembles those observed in seasonal coronavirus infections, implying that the cats who have had SARS-CoV-2 infection “remain at risk of re-infection.”
 
The study team state that this is a similar transient antibody response to also be observed in humans, and that their study should be used going forwards as a “reference for the clinical treatment and prevention of COVID-19.”
 
Dr Jin added, “We suggest that cats have a great potential as an animal model for assessing the characteristic of antibody against SARS-CoV-2 in humans.”
 
The study team state that more research is needed to establish the route of COVID-19 from humans to cats.
 
Dr Jin further added, “Retrospective investigation confirmed that all of antibody positive samples were taken after the outbreak, suggesting that the infection of cats could be due to the virus transmission from humans to cats. Certainly, it is still needed to be verified via investigating the SARS-CoV-2 infections before this outbreak in a wide range of sampling.”
 
 In addition, the study team suggested that some preventive measures should be implemented to maintain a suitable distance between COVID-19 patients and companion animals such as cats and dogs, and hygiene and quarantine measures should also be established for those high-risk animals.
 
For more COVID-19 Warnings, keep on logging to Thailand Medical News.
 

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