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Medical News - HCirV-1 - Human Circovirus 1 - Hepatitis  Feb 08, 2023  1 year, 2 weeks, 6 days, 20 hours, 36 minutes ago

BREAKING! Medical News: Institut Pasteur Discovers New DNA Virus Called Human Circovirus 1 or HCirV-1 That Is Causing Unexplained Hepatitis In Many!

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BREAKING! Medical News: Institut Pasteur Discovers New DNA Virus Called Human Circovirus 1 or HCirV-1 That Is Causing Unexplained Hepatitis In Many!
Medical News - HCirV-1 - Human Circovirus 1 - Hepatitis  Feb 08, 2023  1 year, 2 weeks, 6 days, 20 hours, 36 minutes ago
Medical News: Governments, health authorities, WHO and also the mainstream media has been trying to conceal the debut of a new worrisome virus that is causing the unexplained hepatitis found many including in children the last few months.


 
Thailand Medical News had covered about the mysterious hepatitis occurrences in many children in 2022 in our previous news coverages. Those occurrences are still occurring on a very high level though there is not much coverage about it.
 
Researchers from the Institut Pasteur in France along with scientist from Necker-Enfants Malades Hospital, Inserm, the Université Paris Cité, and the École Nationale Vétérinaire d’Alfort have discovered the human circovirus that is able to infect human and cause hepatitis, in some cases with fatal outcomes.
 
Circovirus is a genus of viruses, in the family Circoviridae. Birds such as pigeons and ducks, and also pigs serve typically as natural hosts, though dogs have been shown to be infected as well.
 
This is the first virus to have crossed over to humans and strangely no one is talking about this discovery.
 
The Circoviruses are single stranded DNA viruses (ssDNA). There are 49 species in this genus. Some members of this genus cause disease such as the PCV-2 virus that causes the postweaning multisystemic wasting syndrome (PMWS).
 
This new human circovirus 1 or HCirV-1 a new virus and there is no details as to how it came about ie whether via lab leaks or from cross-overs involving zoonotic infections. But the fact that there is no coverage about it is a bit concerning!
 
A French site did publish about the discovery and also the study was published I the CDC journal: Emerging Infectious Diseases on the 2nd of February 2023 without any typical press conferences etc!
https://www.pasteur.fr/fr/espace-presse/documents-presse/decouverte-circovirus-implique-hepatite-humaine
 
https://wwwnc.cdc.gov/eid/article/29/2/22-1468_article
 
Though it is increasingly common for viruses to pass from animals to humans, new viruses are rarely discovered. For the last 5 decades there has never been known of any humans getting infected with the circoviruses and though there have been studies being conducted in various bio-safety labs across the world about the PCV-2 virus that causes the postweaning multisystemic wasting syndrome (PMWS0 in certain animals including deers etc.
 
This is however the first case of human circoviruses!
 
This novel HCirV-1 circovirus belongs to a family of small, highly resistant DNA viruses.
 
The circovirus family was first identified in animal species in the 1970s.
 
However, this human circovirus discovered is new and different from the already-known animal circoviruses.&l t;br />  
The discovery was made when a 61-year-old female patient had unexplained chronic hepatitis. She had been receiving immunosuppressive treatment for 17 years in connection with her double “heart-lung” transplant. Thanks to very regular monitoring of her double transplant, the French researchers were able to take numerous pathological tissue samples over several years and, to their shock surprise, identified a new virus.
 
Detailed research showed that it was indeed this new virus responsible for the patient’s hepatitis.
 
The patient’s tissue samples were sequenced using high-throughput sequencing techniques and powerful computer algorithms. The resulting sequences were compared with sequences of known pathogens. This was a new sequence that matched nothing known.
 
Pathological examination of a liver biopsy showed lobular hepatitis, slightly inflammatory, without epithelioid granuloma, substantial portal inflammation and fibrosis, or lymphoproliferation. Results of Ziehl, EBV, CMV, and adenovirus stains and bacteriological examinations of the biopsy sample, including mycobacterial cultures and PCR, broad-range 16S ribosomal RNA gene PCR, were negative. Herpes simplex virus 1 and 2, CMV, adenovirus, and enterovirus PCR results were negative; EBV PCR was positive (135 genome copies/μg DNA, cycle threshold = 35) but not ascribed to acute hepatitis.
 
Overall, the lymphocytic pattern of inflammation in contrast to the lack of eosinophil infiltration, vascular or biliary injuries, and autoimmune liver disease (no plasmocytes), strongly suggested viral hepatitis.
 
The study team considered the extent of both centrilobular necrosis and resorption by macrophages, which suggested recent liver cytolysis. After these first-line negative results from the liver biopsy, the study team conducted metagenomic NGS (mNGS), which revealed presence of the novel circovirus, HCirV-1.
 
The study team further explored and quantified HCirV-1 using quantitative PCR (qPCR) on liver tissue, historical blood samples, feces, bronchoalveolar lavage, urine, and saliva samples from the patient.
 
When we tried to ascertain possible sources of her HCirV-1 infection, the patient reported contact with 2 cats, both of which had contact with birds and rodents. HCirV-1 PCR was negative in the feces of the cats 2 months after her diagnosis. The patient reported no international travel. She did report receiving a blood transfusion 17 months before HCirV-1 was first detected (F
 
The French study team found that the virus can replicate in human liver cells. It uses the cellular machinery to replicate and then destroys the cell. The destruction of a large number of liver cells causes damage to organ function.
 
The patient in this case fortunately had only very mild symptoms.
 
She was able to receive an antiviral treatment, that proved effective in fighting the virus and stopping the destruction of the liver cells. However, it is not yet known how the virus is transmitted (blood, contact, food, etc.).
 
When the study team tried to ascertain possible sources of her HCirV-1 infection, the patient reported contact with 2 cats, both of which had contact with birds and rodents. HCirV-1 PCR was negative in the feces of the cats 2 months after her diagnosis. The patient reported no international travel. She did report receiving a blood transfusion 17 months before HCirV-1 was first detected.
 
In order to ensure that patients infected with this new virus can be treated as quickly as possible, the researchers have already developed a new PCR diagnostic test. This is a rapid and reliable test that can be used in all cases of hepatitis of unknown origin.
 
A new serological test will also be developed soon. This is currently the only known case of human infection with HCirV-1. But thankfully the diagnostic test now available may help us shed light on other cases of hepatitis of unknown origin.
 
It is now being suspected that it is this same new virus that has been causing hepatitis in various patients including kids in the last few months during the COVID-19 pandemic but strangely the U.S. CDC and WHO is refusing to divulge more information or hold any proper press conferences.
 
Finding the origin of this new novel HCirV-1 virus will be very crucial as we strongly believe that something is amiss here!
 
For the latest Medical News, keep on logging to Thailand Medical News.
 
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