Acne Treatments: Researchers Study What Makes the Sarecycline, The First New Antibiotic Approved To Treat Acne In More Than Four Decades Standout
: Acne has always been a nightmare for teenagers and also young adults for literally every decade and despite the vast amount of brands and product ranges of skin cares items; most often have to revert back to a dermatologist to get a dose of oral and topical antibiotics to get rid of the bacteria aggravating the condition. However, dermatologists do not have much of range of antibiotics to choose from as there have not been any new antibiotics developed for a very long time.
Sarecycline, a new antibiotic drug approved for use in the United States in 2018, is the first new antibiotic approved to treat acne in more than 40 years.
In a new study, researchers from Yale University and the University of Illinois-Chicago have discovered how its unique chemical structure makes it effective compared to other antibiotics in its class.
The study findings are published in the journal: Proceedings of the National Academy of Sciences
The new study is the most detailed biological analysis to date for sarecycline, one of a number of tetracycline antibiotics (such as doxycycline and minocycline) used to treat acne.
The study team found that unlike other tetracycline drugs, sarecycline binds to messenger RNA (mRNA) molecules within a cell that provide a code for making proteins in bacterial ribosomes. Ribosomes are found in all living cells, linking amino acids together to form crucial protein be it genes, enzymes etc.
It was found that sarecycline and other tetracyclines treat acne by inhibiting bacterial protein synthesis. They block ribosome function in Cutibacterium acnes, the pathogenic bacterium in acne.
Dr Christopher Bunick, associate professor of dermatology at Yale and co-corresponding author of the study told Thailand medical News via a phone interview, “We show that the structure of sarecycline matters. This mode of action has never been seen before in this class of antibiotics, and suggests that sarecycline has unique properties among the tetracycline class.”
Significantly, the researchers found an explanation for why sarecycline has such a low drug-resistance profile, boosting its effectiveness. Sarecycline thwarts TetM, a ribosome guardian protein that protects bacteria from outside interference.
Dr Bunick and his team said the broader implication of the study is that structural knowledge of tetracycline compounds could be used to engineer better antibiotics.
Dr Bunick further added, “This could result in therapies with better or longer-lasting efficacy, fewer side effects, and lower drug resistance. Future agents could be used not just in acne, but potentially in other skin disorders and infections as well.”
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