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Type 1 diabetes is an inherited condition and individuals with a first degree relative who has the condition are at an increased risk of developing the condition. Details regarding the risk of inheriting type 1 diabetes are given below:
Some genes have repeatedly been identified in people with type 1 diabetes. Among white individuals, examples of such genes include the HLA-DR3 or HLA-DR4 genes. Carrying these genes raises the risk that offspring will inherit type 1 diabetes. Children born with the HLADR3/4-DQ8 genotype make up nearly 50% of all children who develop type 1 diabetes before they are 5 years of age. Some studies on other ethnic groups have shown that similar risks are associated with the HLA-DR7 genotype among African Americans and with the HLA-DR9 gene among Japanese individuals.
Genetic studies have also located HLA class II genes at 6p21 and nearly 40 non-HLA genes that are closely associated with the inheritance of type 1 diabetes.