Weight Loss: Researchers Say Reducing Amino Acids Threonine And Tryptophan In Diet Helps Increases Metabolic Rates And Prevents Weight Gain
: New research findings in a study lead by Monash University’s Biomedicine Discovery Institute (BDI) that also included researchers from University of Kiel-Germany, University Of Melbourne, University Of Sydney, University Of New South Wales and University Of Copenhagen, have provided a new understanding into the roles two essential amino acids (threonine and tryptophan) play in metabolic health, which may help scientists in the fight against obesity.
The result of the research that was led by Dr Adam Rose from Monash University was published in the medical journal: Nature Communications.
The research shows that by reducing the amount of two amino acids ie threonine and tryptophan in young healthy mice, they were able to burn more calories than they consumed, without calorie reduction, keeping them lean and healthy and without the side-effect of lower muscle mass.
Interestingly a low-threonine diet even protected mice that were morbidly obese and prone to developing type 2 diabetes.
Though a moderate reduction in dietary protein and therefore essential amino acids can enhance vitality, diets devoid of this component can make individuals sick very quickly and are not recommended.
This study however has shown that a reconsideration of the functions of these two amino acids in nutrition warrants further exploration.
Dr Rose told Thailand Medical News, "Once we understand which particular dietary components are needed for the health-promoting effects of these diets we can design strategies to mimic them, simulating the effects without having the negative side effects.”
A key component of the study was an experiment where Dr Rose and the rest of the researchers genetically manipulated the mice to be able to synthesize the essential amino acid threonine, which blocked the health promoting effects of the low threonine diet and saw the mice gain weight, proving that these two amino acids can hold the key to a new diet approach.
"New research is showing an increasing number of situations in which essential amino acids are powerful modulators of lifelong health and lifespan. These new research findings on their specific effects gives us exciting insights into how we might harness their benefits to drive better health," said Dr Matthew Piper, a key co-author or the study who is also from Monash University.
Professor Dr Stephen Simpson from the University of Sydney's Charles Perkins Centre further added, "We are beginning to understand how critical the balance of dietary amino acids is to the control of appetite, weight, health and aging."
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