Genomics and Epigenetics - Thailand Medical News

TYK2, A Gene Associated With Lupus Provides Protection Against SARS-CoV-2 Infection And COVID-19 Severity But Increases Risk For Autoimmune Disease

Source: Medical News - TYK2 Gene Prevents COVID-19 Severity Nov 04, 2022 1 year ago

Researchers from King’s College London - United Kingdom have discovered that the gene TYK2 that is associate with systemic lupus erythematosus (SLE) provides protection against SARS-CoV-2 infections and also prevents COVID-19 severity but increases the risk for autoimmune diseases. The study team observed a correlation between the genetic associations with severe COVID-19 and those ...

Urgent Studies Needed To Assess If SARS-CoV-2 Can Cause Missense Mutations In Human DNA And Give Rise To New Medical Conditions Never Seen Before!

Source: Medical News - SARS-CoV-2 Induced Human Missense Mutations Jul 25, 2022 2 years ago

Thailand Medical News is once again proposing another new hypothesis, this time that SARS-CoV-2 infections can cause missense mutations in the human DNA and genes and give rise to new medical conditions never seen before. A missense mutation occurs when there is a mistake in the DNA code and one of the DNA base pairs is changed, for example, A is swapped for C. This single change m...

Human Genes Play Role In COVID-19 Infections, Symptoms And Disease Progression According To International Study

Source: Human Genes Aug 27, 2020 4 years ago

Human Genes: A new international collaborative study shows that human host genes also play a role in the COVID-19 infections, symptoms and also progression of the disease. The study findings were published on a preprint server and have yet to have been peer-reviewed. https://www.medrxiv.org/content/10.1101/2020.08.21.20177246v1 COVID-19 causes a broad spectrum of symptoms from none at all...

Gene That Causes Cardiomyopathy And Blindness Discovered Along With Treatment Using Taurine Supplements

Source: Thailand Medical News Feb 01, 2020 4 years ago

Swiss researchers from University Of Geneva (UNIGE) have discovered a new gene that causes blindness and cardiomyopathy. They have also managed to halt the progression of eye disease and treat cardiac disease by administering a food supplement called taurine. The human genome consists of 20,000 genes, all of which may be capable of triggering disease. It is estimated that there are 7...

New Study Reveals Most Commercial Lab Conducting Genetic Sequencing Tests Routinely Fail to Analyze Large Segments of DNA, Hence Lacking Accuracy

Source: Thailand Medical News Jan 07, 2020 4 years ago

New Study Reveals Most Commercial Labs Conducting Genetic Sequencing Tests Routinely Fail to Analyze Large Segments of DNA, Hence Lacking Accuracy. A review of clinical tests from three major U.S. laboratories by UT Southwestern Medical Center experts shows whole exome sequencing routinely fails to adequately analyze large segments of DNA, a potentially critical deficiency that can preven...

New Genetic Signature For Accurately Predicting Breast Cancer

Source: Thailand Medical News Dec 19, 2019 4 years ago

Genome and oncology researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases. The new research combined a study of the genes involved in retinop...

Non-Coding SNPs Plays A Role In Inherited Risk of Cancer

Source: Thailand Medical News Dec 09, 2019 4 years ago

An individual’s risk of developing cancer is affected by genetic variations in regions of DNA that don’t code for proteins, previously dismissed as ‘junk DNA’, according to new research published in the British Journal of Cancer last week. Professor Dr John Quackenbush, from Harvard T.H. Chan School of Public Health and lead author of the study told Thailand Me...

HDAC9 Gene Identified As Playing Role In Hardening Of Blood Vessel Walls

Source: Thailand Medical News Nov 30, 2019 4 years ago

Researchers from Massachusetts General Hospital have identified a specific gene, the HDAC9 gene in the calcification of the human aorta, the largest blood vessel in the body. Typically, Cardiovascular Arterial wall calcification is the buildup of calcium in the blood vessel walls, which can often be a predictor of serious cardiovascular events like heart attacks and strokes. Scientists have long ...

New CRUP Program Makes Enhancer Prediction Fast And Easy For Geneticists

Source: Thailand Medical News Nov 28, 2019 4 years ago

Typically, It is the wish of every molecular geneticist: an easy-to-use program that compares data sets from different cellular conditions, identifies enhancer regions and then assigns them to their target genes. A research team led by Martin Vingron at the Max Planck Institute for Molecular Genetics in Berlin has now developed a program that masters all of this. Dr Martin Vingron, Director and H...

Researchers From Uppsala University, Sweden Using Genome Sequencing To Identify More Inflammatory Biomarkers

Source: Thailand Medical News Nov 24, 2019 4 years ago

Researchers from Uppsala University, Sweden in a new study have shown that whole-genome sequencing increases the precision of genetic studies, which in turn can improve our perspectives of how to use biomarkers to discover disease. The results are published in the scientific journal Scientific Reports. Typically, biomarkers, such as specific proteins circulating in our blood stream, are...

Study Links Non-Coding DNA To Brain Cancer And Possibly Other Cancers

Source: Thailand Medical News Nov 22, 2019 4 years ago

Typically, one of the ways a cancer-causing gene works up enough power to turn a normal cell into a cancer cell is by copying itself over and over, like a Xerox machine. Scientists have long noticed that when cancer-causing genes do that, they also scoop up some extra DNA into their copies. But it has remained unclear whether the additional DNA helps drive cancer or is just along for the ride. ...

New CRISPR/Cas9 ‘Targeted Disruption’ Therapy To Suppress Aging

Source: Thailand Medical News Nov 18, 2019 4 years ago

Salk Institute researchers have developed a new gene therapy to help decelerate the aging process. Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer's disease, to name a few. This makes the need for anti-aging therapies all the more urgent. The research findings, published in the journal Nature Medicine, highligh...

GSTM1 Gene Determines Which Individuals Can Benefit from Dietary Protectants That Prevent Kidney Failure

Source: Thailand Medical News Nov 15, 2019 4 years ago

A new study by the University of Rochester Medical Center New indicates that the benefits of a dietary compound on kidney health may depend on an individual's genetics. The findings may be helpful for tailoring interventions to prevent or treat kidney disease. GSTM1 or Glutathione S-transferase mu-1 is an enzyme that plays a role in ridding the body of toxins and combatting oxidative stress...

Novo Nordisk Develops New Genome Editing Tool for Actinomycetes : CRISPR-BEST

Source: Thailand Medical News Nov 10, 2019 4 years ago

Researchers from Novo Nordisk Foundation Center for Biosustainability, DTU Biosustain have developed a new genome editing tool tool called the CRISPR-BEST. Although existing CRISPR technologies allow for better manipulation of genomes with many positive effects on modern drug development and the discovery of new and better antibiotics, significant problems such as genome instability and toxicity o...

Identifying Vulnerabilities In Cancer Using CRISPR

Source: Thailand Medical News Oct 31, 2019 5 years ago

A group of genomic researchers led by Dr Julián Cerón of the Bellvitge Biomedical Research Institute (IDIBELL), has taken advantage of the similarity between the amino acids and genes of humans and the nematode Caenorhabditis elegans and their expertise in CRISPR gene editing to mimic in C. elegans, the SF3B1 mutations found in human tumors. Although the one-millimeter worm t...

Genomic Researchers Modify CRISPR Technology To Fight Viruses in Human

Source: Thailand Medical News Oct 26, 2019 5 years ago

Cas13, a common gene-editing enzyme could be used to disable RNA viruses such as flu, Zika or Ebola. CRISPR is usually thought of as a laboratory tool to edit DNA in order to fix genetic defects or enhance certain traits but in reality, the mechanism originally evolved in bacteria as a way to fend off viruses called bacteriophages. Researchers have previously adapted the Cas13 enzyme as a...

“Prime Editing”, A New CRISPR Genome Editing System Sets To Revolutionize Genomics

Source: Thailand Medical News Oct 22, 2019 5 years ago

A genomic research team from the Broad Institute of MIT and Harvard have developed a new revolutionary CRISPR genome-editing approach by combining two of the most important proteins in molecular biology : CRISPR-Cas9 and a reverse transcriptase into a single machine. Credit : Susanna M. Hamilton, Broad Institute Communications The new platform , called “prime editing,&rdqu...

Study Reveals Mutations in “Junk” DNA Causes Autism and Opens New Perspectives In Genomics

Source: Flatiron Institute's Center for Computational Biology (CCB) May 29, 2019 5 years ago

Researchers in New York, leveraging on artificial intelligence techniques, have demonstrated that mutations in so-called 'junk' DNA can cause autism .This study is the first to functionally link such mutations to the neurodevelopmental condition. Led by Olga Troyanskaya , deputy director for genomics at the Flatiron Institute's Center for Computational Biology (CCB) in New Yor...

Gene LRRK2 Involved In Causing Parkinson’s Identified with New Treatment Protocols On The Way

Source: University of Oxford May 04, 2019 5 years ago

The discovery of a new way to target and treat the leading genetic contributor to Parkinson's may open the way for a potential new clinical treatment. Researchers from Oxford's Department of Physiology, Anatomy and Genetics (DPAG) have identified how the dysfunction of a key gene, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell c...

Common liver cancer gene identified for therapeutic approaches

Source: The Translational Genomics Research Institute Apr 09, 2019 5 years ago

Hepatocellular carcinoma (HCC) is a long medical name for the most common form of liver cancer, a malignancy whose incidence has nearly doubled over the past decade, making it the fastest growing type of cancer in the U.S., and the third-leading cause of cancer-related death worldwide. Researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, provide the...

Protein production efficiency can be predicted by gene sequence

Source: Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Brazil Feb 07, 2019 5 years ago

Scientists explored mRNA and protein public databases to unravel hidden meanings of the genetic code. Using a metric derived from mRNA codon composition, they found out how gene sequence choice can predict different aspects of protein synthesis, such as protein production efficiency. The study could help the development of new biotechnological applications of genes and proteins. Today, thousand...

Genome study reveals new routes to treating osteoarthritis

Source: Wellcome Trust Sanger Institute Jan 22, 2019 5 years ago

In the largest genetic study of osteoarthritis to date, scientists have uncovered 52 new genetic changes linked to the disease, which doubles the number of genetic regions associated with the disabling condition. Scientists at the Wellcome Sanger Institute, GSK and their collaborators analysed the genomes of over 77,000 people with osteoarthritis. Their findings, published in Nature ...

Common genetic markers of tumor hypoxia across 19 cancer types discovered.

Source: Ontario Institute for Cancer Research Jan 15, 2019 5 years ago

Researchers at the University of Toronto have discovered mutational signatures of tumor hypoxia (low oxygen) in 19 cancer types. The results could be used to help clinicians identify patients who would benefit from higher treatment doses. In a landmark pan-cancer study analyzing more than 8,000 tumors across 19 different cancer types, researchers have identified molecular hallmarks of...

Genome that reduces GSTT2 Expression responsible for Esophageal Cancer Disparity

Source: University of Michigan Jan 01, 2019 5 years ago

A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds. It suggests a possible target for prevention strategies, which preliminary work suggests could involve flavonoids derived from cranberries. "We've known for a long time that esophageal adenocarcinoma primarily affects Caucasians and ver...

1 in 10 cases of chronic kidney disease are caused by Genes.

Columbia University Irving Medical Center Dec 27, 2018 5 years ago

A new study has found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and that identifying the responsible genes has a direct impact on treatment for most of these patients. “Our study shows that genetic testing can be used to personalize the diagnosis and management of kidney disease, and that nephrologists should consider incorporating it into the diagnost...

Study Identifies 35 kidney genes linked to chronic kidney disease.

Source: University Of Manchester Nov 23, 2018 5 years ago

An international study lead by University of Manchester scientists has discovered the identity of genes that predispose people to chronic kidney disease. The discovery is a major advance in understanding of the significantly under-diagnosed disorder which, if left undetected, can lead to failing kidneys that need dialysis or kidney transplantation. The discovery of 35 kidney &n...

Discovery of LZTR1 leads to insights into RAS-driven diseases

Source: VIB (The Flanders Institute For Biotechnology) Nov 19, 2018 5 years ago

Mutations in RAS proteins initiate many of the most aggressive tumors, and the search for pharmacological inhibitors of these proteins has become a priority in the battle against cancer. Michail Steklov, Francesca Baietti, and colleagues from the Anna Sablina lab (VIB-KU Leuven Center for Cancer Biology) identified LZTR1 as an evolutionarily conserved component of the RAS pathway. Multiple ...

Solving Irritable Bowel Diseases by detecting epigenetic signatures.

Source: Cincinnati Children's Hospital Medical Center Nov 06, 2018 6 years ago

Study points to possible way to predict increased inflammation risk With an estimated 40 million people in the world dealing with inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report in the journal JCI Insights finding an ep...

First Comprehensive Human Cancer Gene Census creates opportunities for targeted and personalized treatments.

Source: Wellcome Trust Sanger Institute Oct 25, 2018 6 years ago

Researchers at the Wellcome Sanger Institute have created the first comprehensive summary of all genes known to be involved in human cancer, the Cancer Gene Census. Describing all genes strongly implicated in causing cancer, the Census also describes how they function across all forms of this disease. Reported in Nature Reviews Cancer, the resource catalogues over 700 genes, to help scientist...

New analysis of about 4,000 mutations deliberately engineered into the BRCA1 gene to benefit breast or ovarian genetic screenings.

Source : University of Washington Health Sciences/UW Medicine Sep 18, 2018 6 years ago

Jay Shendure and Lea Starita, faculty in the Department of Genome Sciences at the University of Washington School of Medicine, are the senior authors. Shendure directs the Brotman Baty Institute for Precision Medicine in Seattle, which helped support the study. Starita co-directs the Brotman Baty Advanced Technology Lab. Shendure is also a Howard Hughes Medical Institute investigator. Greg Findla...

Researchers identify protein that is responsible for cellular memory during cell division.

Source: University of Copenhagen The Faculty of Health and Medical Sciences Aug 28, 2018 6 years ago

With a new groundbreaking technique, researchers from University of Copenhagen have managed to identify a protein that is responsible for cellular memory being transmitted when cells divide. The finding is crucial for understanding development from one cell to a whole body. The cells in our body divide constantly throughout life. But how do cells remember whether to develop into a skin, liver or ...

Genome editing method targets AIDS virus

Source: Kobe University Aug 08, 2018 6 years ago

By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, a Japanese research group has succeeded in blocking the production of HIV-1 by infected cells. Human immunodeficiency virus-1 (HIV-1) infection is a chronic disease affecting more than 35 million people worldwide. The infection can be controlled by antiretroviral therapy (ART), but the...

Tea consumption leads to epigenetic changes in women

Source: Uppsala Universitet Jul 23, 2018 6 years ago

Epigenetic changes are chemical modifications that turn our genes off or on. In a new study, researchers show that tea consumption in women leads to epigenetic changes in genes that are known to interact with cancer and estrogen metabolism. Epigenetic changes are chemical modifications that turn our genes off or on. In a new study from Uppsala University, researchers show that tea consum...

Genes That Increase the Risk of Pancreatic Cancer Identified

Source: Mayo Clinic Jul 21, 2018 6 years ago

Six genes associated with pancreatic cancer have been identified by a research team at Mayo Clinic. The team finds that these genes can be inherited but are also present in patients with no family history of pancreatic cancer. The team recommends genetic testing for all pancreatic cancer patients as the new standard of care. ‘Six genes contain mutations that can be inherited ...

Genetic Variants Can Highlight Possible Drugs for Inflammatory Bowel Disease

Source: Wellcome Trusts Sanger Institute Jul 11, 2018 6 years ago

Genetic variants can increasingly be used to connect patients to treatments as well as uncover new therapeutic targets. Jeffrey Barrett, formerly of the Wellcome Trust Sanger Institute, described how prioritizing genome-wide association study results has uncovered drugs that could be used to treat inflammatory bowel disease. Functional Studies on the IBD Susceptibility Gene IL23R I...

Importance of Epigenetics in tracking environmental impact on genomes

Source: Johns Hopkins Medicine Jul 10, 2018 6 years ago

In a review article published in the New England Journal of Medicine, scientist Andrew Feinberg, M.D., calls for more integration between two fields of DNA-based research: genetics and epigenetics. Most people are familiar with genetics, a field of research that focuses on the precise sequence of chemicals that form the ladder-like structure of DNA. However, epigenetics is not as wel...

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