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Source: Bacterial Disinfectants  Jun 24, 2020  2 years ago
Bacterial Disinfectants: New Yeast Biosurfactant To Combat Bacterial Biofilms in Food Processing Industries, Restaurants, Kitchens and Also Healthcare Industry
Bacterial Disinfectants: New Yeast Biosurfactant To Combat Bacterial Biofilms in Food Processing Industries, Restaurants, Kitchens and Also Healthcare Industry
Source: Bacterial Disinfectants  Jun 24, 2020  2 years ago
Bacterial Disinfectants: Typically existing inside pipes and on the surfaces of indwelling medical devices, slimy layers of bacteria, called biofilms, cause problems ranging from large-scale product contamination to potentially fatal chronic infections.


 
Such biofilms are notoriously difficult to eliminate, not surprising given that one of their main roles is to protect encased bacteria from threats such as predation, antibiotics, and chemical cleaning agents.

To date, bleach, harsh oxidizing cleaning products, and petrochemical-derived detergents called surfactants combined with scrubbing are the most effective methods of removing biofilms. However, bleach and harsh chemicals are obviously unsuitable for use in biological settings, and while surfactants are used in products such as hand soap and cosmetics, many are toxic to the environment and can damage the surfaces that they are used on.

A new study published in the peer-reviewed journal: Langmuir highlights how researchers from the University of Tsukuba in Japan have found a new way of tackling biofilms, using cleaning agents derived from microbes themselves. https://pubs.acs.org/doi/10.1021/acs.langmuir.0c00643

Co-lead author Professor Dr Andrew Utada told Thailand Medical News, “Certain Candida yeasts can naturally produce biosurfactants called sophorolipids during the fermentation of oils. Past studies have shown that sophorolipids have some degree of antimicrobial activity, but there is conflicting information on the effects of these compounds on biofilms composed of the Gram-negative pathogen Pseudomonas aeruginosa.”

Often gram-negative bacteria such as P. aeruginosa and Escherichia coli are a major cause of hospital-acquired infections, killing thousands of people every year. Using microfluidic channels, the study team showed that sophorolipids do a better job of disrupting established P. aeruginosa biofilms than commonly used chemical surfactants.
 
However surprisingly there was no evidence that sophorolipids actually killed the bacteria. A mutant P. aeruginosa strain that produces excessive amounts of biofilm matrix was therefore used to examine the underlying mechanism of biofilm dispersal, revealing that sophorolipids appear to weaken the interaction between the biofilm and the underlying surface and break the internal cohesiveness of the biofilm itself, leading to disruption.

Though biosurfactants are biodegradable and far less harmful to the environment than their chemical counterparts, they are costly to produce. To address this issue, the researchers tested the effects of sophorolipids in combination with the widely used chemical surfactant sodium dodecyl sulfate, with encouraging results.

Dr Bac Nguyen a co-researcher of the study said, “Combination testing revealed a synergy between sophorolipids and chemical surfactants, with the two agents together demonstrating stronger antibiofilm effects at concentrations about 100-fold lower than when either one was used in isolation.”

Though reducing the costs associated with the production of biosurfactants is the long-term goal, this synergistic approach to biofilm elimination may open new doors for the treatment of persistent bacterial biofilm-mediated infections. 
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