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Source: Thailand Medical News   Dec 26, 2019  3 years, 11 months, 1 week, 5 days, 22 hours, 21 minutes ago

Pharma Giant Roche Purchases Rights To DMD Gene Therapy By Sarepta

Pharma Giant Roche Purchases Rights To DMD Gene Therapy By Sarepta
Source: Thailand Medical News   Dec 26, 2019  3 years, 11 months, 1 week, 5 days, 22 hours, 21 minutes ago
Pharma Industry News

Roche and Sarepta have signed a legal deal providing Roche exclusive commercial rights to SRP-9001 (AAVrh74.MHCK7.micro-dystrophin), Sarepta’s investigational gene therapy for Duchenne muscular dystrophy (DMD), outside the United States.

Under the terms of the deal, Sarepta will receive US$1.15 billion in an upfront payment and an equity investment; up to $1.7 billion in regulatory and sales milestones; and royalties on net sales, anticipated to be in the mid-teens.

The deal also stipulates that  Roche and Sarepta will equally share global development expenses, the firms revealed in a media release.

The enw deal also lets Sarepta retains all rights to SRP-9001 in the United States.

Duchenne muscular dystrophy or DMD is an X-linked rare degenerative neuromuscular disorder causing severe progressive muscle loss and premature death.

The gene therapy: SRP-9001,currently in clinical development for DMD, is designed to deliver the micro-dystrophin-encoding gene directly to the muscle tissue for the targeted production of the micro-dystrophin protein.

Doug Ingram, President and Chief Executive Officer, Sarepta told Thailand Medical News via a phone interview,  “This collaboration will not only increase the speed with which SRP-9001 could benefit DMD patients outside the United States, but will also greatly expand the scope of territories within which we could potentially launch SRP-9001 and improve and save lives.”

More News On Sarepta
Sarepta’s Surprise FDA Approval For Rare Disease Drug Excites Pharma Market
The US FDA’s out-of-the-blue approval of Sarepta Therapeutics’ second Duchenne muscular dystrophy (DMD) drug sent the company’s stock soaring on Friday. Shares of Sarepta SRPT, -0.94%  jumped 35% in morning trading after Thursday evening’s Vyondys 53 approval.

Duchenne muscular dystrophy or DMD is a rare disorder that mainly affects male children. About 8% of the children who have DMD have the gene mutation that Vyondys 53 treats.

Sarepta’s Vyondys 53 approval removes a major overhang f or the stock as concerns surrounding the future SRPT’s commercial products such as Exondys 51 being pulled from the market and cash flows required to support SRPT’s growing gene therapy platforms have now been lifted. Sarepta already markets Exondys 51, which was the first FDA-approved DMD treatment in 2016. And until now, it has been the company’s only commercialized therapy, bringing in $99 million in sales in the third quarter, up from $78 million in the same period a year ago.

Till Aug. 19, when the regulator sent a complete response letter to the company citing a pair of risk concerns about the then experimental therapy, it was expected that Vyondys 53 would follow the same accelerated pathway as Exondys 51. The company’s stock tumbled 18% to $120.31 that day and has since failed to recover to its year-to-date high of $156.91 on July 15. The stock closed Thursday at $100.47. Company officials said they were surprised by the letter at that time.
Sarepta president and CEO Doug Ingram said in a news release, “In the span of four months, we commenced and completed the formal dispute resolution process culminating in the grant of our appeal, resubmitted our [new drug application] and obtained an approval–a great benefit to DMD patients awaiting treatment.”

A Sarepta spokeswoman said Exondys51 and Vyondys53 both have an annual list price of approximately $300,000.
The expensive price tag has raised questions among experts even though there are limited treatment options for DMD patients. The Institute for Clinical and Economic Review, a watchdog that conducts comparative clinical effectiveness research, said in August that most insurers have responded to the high price of Exondys 51 by narrowing coverage. “Three years after approval, the manufacturer has provided no high-quality evidence of benefit, many patients and families are surely losing out, and only the manufacturer truly benefits from this deplorable situation,” ICER chief medical officer David Rind said in a statement then.

Sarepta is also developing casimersen, another experimental DMD treatment that is expected to receive an FDA decision in the first half of next year. But not all analysts believe that the approval of Vyondys 53 bodes well for the FDA’s take on casimersen and other DMD medications in the industry pipeline.


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