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BREAKING NEWS
Source: SARS-CoV-2 Variant News  Jun 24, 2021  2 years, 9 months, 3 weeks, 3 days, 8 hours, 53 minutes ago

BREAKING NEWS! Study Confirms P681R Mutation Found On Delta Variant Has Special Infection Strategy And Can Evade Immunity Induced By Vaccination Or Natural Infection!

BREAKING NEWS! Study Confirms P681R Mutation Found On Delta Variant Has Special Infection Strategy And Can Evade Immunity Induced By Vaccination Or Natural Infection!
Source: SARS-CoV-2 Variant News  Jun 24, 2021  2 years, 9 months, 3 weeks, 3 days, 8 hours, 53 minutes ago
Variant News: Japanese scientists have conducted a new research in which the findings show that the B.1.617 lineage of the SARS-CoV-2 coronavirus that emerged in India has evolved a unique strategy to facilitate infection and evade the immunity induced by vaccination or natural infection.

Numerous mutations have been accumulated in the viral genome, and at least five variants of concerns (VOCs) have been considered as the hazardous SARS-CoV-2 variants to the human society.
 
The newly emerged VOC, the B.1.617.2 lineage (delta variant), closely associates with a huge COVID-19 surge in India in Spring 2021. However, its virological property remains unclear.
 
The study team shows that the B.1.617 variants are highly fusogenic and form prominent syncytia. Bioinformatic analyses reveal that the P681R mutation in the spike protein is highly conserved in this lineage. Although the P681R mutation decreases viral infectivity, this mutation confers the neutralizing antibody resistance. Notably, we demonstrate that the P681R mutation facilitates the furin-mediated spike cleavage and enhances and accelerates cell-cell fusion. Our data suggest that the P681R mutation is a hallmark characterizing the virological phenotype of this newest VOC, which may associate with viral pathogenicity.
 
The study findings were published on a preprint server and are currently being peer reviewed. https://www.biorxiv.org/content/10.1101/2021.06.17.448820v1
 
Alarmingly, the SARS-CoV-2 virus, responsible for the COVID-19, continues to threaten global public health and the worldwide economy.
 
Detailed bioinformatic analysis revealed that the mutation P681R is highly conserved in the viral spike protein of the B.1.617 lineage. The spike protein mediates the initial stage of the infection process when its receptor-binding domain (RBD) attaches to the host cell receptor angiotensin-converting enzyme 2 (ACE2).
 
The study team showed that the presence of P681R significantly enhanced the efficacy of viral fusion, promoted cell-to-cell infection, and was associated with the formation of prominent syncytia. Syncytia are multinucleated cells that arise through the fusion of uninuclear cells.
 
The team says that the P681R-mediated kinetics of viral fusion may not only contribute to immune escape but also more severe disease among individuals exposed to SARS-CoV-2.
 
Dr Kei Sato from the University of Tokyo told Thailand Medical News, “Our data suggest that the P681R mutation is a hallmark characterizing the virological phenotype of this newest variant of concern, which may be associated with viral pathogenicity.”
After the identification of the original SARS-Co