Thailand Medical News - For All The Latest Breaking Medical News, Health News, Research News, COVID-19 News, Outbreak News, Dengue News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Heart And Cardiology News, Epigenetic News, Cancer News,

BREAKING NEWS
Source: Thailand Medical News  Nov 23, 2019  4 years, 4 months, 5 days, 18 hours, 37 minutes ago

University Of California, Irvine-Led Study Reveals How Weekend Alcohol Binge Drinking Affects The Circadian Rhythm Of The Liver Leading To Disease

University Of California, Irvine-Led Study Reveals How Weekend Alcohol Binge Drinking Affects The Circadian Rhythm Of The Liver Leading To Disease
Source: Thailand Medical News  Nov 23, 2019  4 years, 4 months, 5 days, 18 hours, 37 minutes ago
University Of California, Irvine researchers conducted a new study that reveals how alcohol affects the liver's circadian rhythm, uncovering a potential new target for ALD treatments.  Weekend binge drinking and chronic alcoholism have long been known to contribute to alcoholic liver diseases (ALD). 



Alcohol consumption is a widespread habit in modern society and can have serious metabolic consequences.  Recent studies have uncovered the interplay between nutrition, metabolism and circadian rhythms. But, until now, little has been done to understand the effects of alcohol consumption on circadian metabolism.

The new study, titled, "Distinct Metabolic Adaptation of Liver Circadian Pathways to Acute and Chronic Patterns of Alcohol Intake," was published today in Proceedings of National Academies of Science. 

The researchers used mice to analyze the effects of binge and chronic exposure to ethanol. They revealed that distinct drinking patterns elicit profoundly different effects through distinct cellular pathways, leading to differential adaptation of hepatic circadian metabolism. 

Dr Paolo Sassone-Corsi, director of the UCI School of Medicine Center for Epigenetics and Metabolism and senior author of the study told Thailand Medical News, "Our results showed how drinking patterns reprogrammed circadian metabolism in the liver. By understanding how the circadian process is involved in alcoholic liver disease, we can begin to target circadian therapeutics to develop better treatments."

In previous studies, Dr Sassone-Corsi examined how circadian clocks can be rewired by such factors as sleep deprivation, diet and exercise. He has also discovered that the circadian clock in the liver has intrinsic functions that are independent from other organs in the body, including the brain.

This new study underscores the link between circadian rhythms and alcohol metabolism.  When consumed, alcohol is primarily metabolized in the liver and is a prominent risk factor for the development of ALDs which include alcoholic hepatitis, cirrhosis and liver cancer, among others.

University of California,Irvine researchers involved in the study included primary investigators Jonathan Gaucher and Kenichiro Knouchi, as well as Emilie Montellier, Carolina Magdalen Greco, Selma Masri and Pierre Baldi.  Other researchers, from LMU Munich and the Leibniz Institute for Farm Animal Biology in Germany, and the Qingdao University in China, also contributed.

The research was supported by the National Cancer Institute of the US National Institutes of Health, the European Research Council, INSERM, DARPA and in part by the Pilot Project Program of NIAAA-funded Southern California Research Center for ALPD and Cirrhosis, among other funding sources.
/>
Reference: Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake, Jonathan Gaucher, Kenichiro Kinouchi, Nicholas Ceglia, Emilie Montellier, Shahaf Peleg,  Carolina Magdalen Greco, Andreas Schmidt, Ignasi Forne, Selma Masri, Pierre Baldi, Axel Imhof, and Paolo Sassone-Corsi, PNAS first published November 22, 2019 https://doi.org/10.1073/pnas.1911189116

MOST READ

Jun 10, 2023  10 months ago
COVID-19 News - DNA Methylation - Asymptomatic SARS-CoV-2 Infections
Sep 08, 2022  2 years ago
Source- Medical News - COVID-19 Research - Impaired Pain Modulation
Aug 04, 2022  2 years ago
Source: Medical News - SARS-CoV-2 & Cancer
Aug 13, 2020  4 years ago
Source: Supplements For COVID-19