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Read all about the latests in HIV/Aids research and treatment protocols and also developments made into various specific components of managing this disease that is by itself also evolving.
Source: Thailand Medical News Sep 25, 2019 7 years ago
Thailand Medical News is pleased to present this simple guide with regards to essential micronutrients, health supplements and herbal products for people living with HIV. It is not mean for anyone to abstain from their prescribed antiretroviral therapies and before commencing any consumption any of these products, always consult your doctors first.
Micronutrients
All vitamins and minerals are ...
Source: Thailand Medical News Sep 24, 2019 7 years ago
CAR-T, a type of immunotherapy may have made its name as the cancer breakthrough of this century, but its roots dig far back to one of humanity’s other terrifying medical enemy: HIV. CAR-T is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then t...
Source: Thailand Medical News Sep 23, 2019 7 years ago
Longterm patients will ultimately face increased incidence of heart disease, COPD, Tuberculosis and bone fractures according to a new study. These are the areas that HIV patients need to take extra care off besides their antiretroviral regimens.
Academics from Anglia Ruskin University (ARU) in Cambridge and the Medical University of Vienna conducted the first ever large-scale review into th...
Source: Thailand Medical News Sep 21, 2019 7 years ago
For those on Antiretroviral therapy for prevention or treatment of HIV, whether on a single pill or combo regimen, it can be burdensome making sure the drugs are consumed without fail at the right times despite having a busy daily schedule. Those days might soon be over thanks to medical researchers across multiple departments at the University of North Carolina who collaborated on a seven-y...
Source: Thailand Medical News Sep 20, 2019 7 years ago
Results of a study that was conducted in South Africa using the RV144/Thai vaccine regimen that showed modest protection in an efficacy study conducted in Thailand, where clades B and E are prominent indicated significant cellular and antibody responses in study participants with clade C as the dominant circulating strain of HIV.
"Trial Responses Dispels The Notion That Each Strain or Clade...
Source: Thailand Medical News Aug 08, 2019 7 years ago
A new potential medication that works with an HIV-infected person's own body to further suppress the ever present but silent virus that available HIV treatments are unable to combat has been discovered by a team of medical scientist from University of Texas Medical Branch at Galveston.
In an exclusive interview with Thailand Medical News, lead author Assistant Professor Haito Hu comme...
Source: Thailand Medical News Jul 15, 2019 7 years ago
Findings from the recent START study involving 4684 adult HIV-positive patients from various countries showed that starting antiretroviral therapy (ART) has significant benefits and entails few risks for individuals with a low pre-treatment viral load. All the patients in the study had a CD4 cell count above 500 cells/mm3 and were randomised to start immediate ART or to defer therapy until th...
Source: Thailand Medical News Jun 22, 2019 7 years ago
New immunity cells known as CD11c+ dendritic cells have been identified by a team of researchers from The Westmead Institute For Medical Research in Sydney.These CD11c+ dendritic cells are extremely susceptible to the HIV virus and can transmit the virus to other cells especially the CD4 T Cells.
These CD11c+ dendritic cells are a type of dendritic cells that play a role in capturing any i...
Source: Thailand Medical News Jun 04, 2019 7 years ago
Most HIV patients have a 60% risk of developing a form of cancer during their life-span.
Cancers like Lymphoma, Lung Cancer, Anal Cancer, Cervical Cancer, Oral and oropharyngeal cancer ,liver cancer, skin cancer and also Kaposi's sarcoma are most prevalent among HIV patients.
At the recent ASCO presentation, study led by doctors at Fred Hutchinson Cancer Research Center showed that pati...
Source: La Jolla Institute for Immunology, California May 11, 2019 7 years ago
A new HIV vaccine delivery strategy appears to enhance the protective immune response in a preclinical model. Scientists at the La Jolla Institute for Immunology (LJI) have discovered that delivering an HIV vaccine in small doses over a series of days leads to a stronger immune response than when the same vaccine is given all at once.
A similar escalating dose method could be the best way...
Source: NIH/National Institute of Allergy and Infectious Diseases,US Apr 18, 2019 7 years ago
Regular infusions of an antibody that blocks the HIV binding site on human immune cells may have suppressed levels of HIV for up to four months in people undergoing a short-term pause in their antiretroviral therapy (ART) regimens, according to a report published online today in The New England Journal of Medicine. Results of the Phase 2, open-label study indicate the antibody, known as UB-42...
Source: The London School of Medicine (Blizard Institute) Apr 05, 2019 7 years ago
A recent research found that long-term cotrimoxazole treatment reduces mortality and morbidity in children with HIV by altering their gut microbiome and immune activation.
The finding supports current WHO guidelines, which recommend long-term cotrimoxazole treatment for all HIV-positive people living in areas where malaria and severe bacterial infections are common.
Previous studies have shown...
Source: Conference on Retroviruses and Opportunistic Infections (CROI 2019) ,Seattle. Mar 10, 2019 7 years ago
A combination of two long-acting injectable anti-HIV drugs taken once monthly had a very low rate of treatment failure and a favourable safety profile, according to results from two phase III trials presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2019) in Seattle.
Dual injections of cabotegravir, an experimental integrase inhibitor, and the no...
Source: George Mason University Feb 15, 2019 7 years ago
George Mason University's Yuntao Wu is the lead scientist on a research team that has identified a measurable indicator that could prove instrumental in the fight against HIV.
The research focuses on cofilin, a key protein that regulates cells to mobilize and fight against infection.
In an HIV-infected patient, cofilin dysfunction is a key factor in helper T cell defects, according to the r...
Source: Simon Fraser University Feb 03, 2019 7 years ago
The immune system is the body's best defense in fighting diseases like HIV and cancer. Now, an international team of researchers is harnessing the immune system to reveal new clues that may help in efforts to produce an HIV vaccine.
SFU professor Mark Brockman and co-authors from the University of KwaZulu-Natal in South Africa have identified a connection between infection cont...
Source: Howard Hughes Medical Institute Jan 31, 2019 7 years ago
Researchers can now quickly and accurately count a hidden, inactive form of the human immunodeficiency virus (HIV) that lurks in patients' cells. This version of HIV embeds into cells' genomes and can persist despite otherwise successful therapies, thwarting attempts to cure the infection.
Using a new genetic technique developed by Howard Hughes Medical Institute Investigator Robert Sil...
Much of the research on HIV has focused on preventing infection but little is understood about how the body keeps the virus in check post-infection. A new study by Yale investigators reveals the role of a protein that serves to block HIV gene expression once it has entered human cells.
The research team, led by Manabu Taura, a postdoctoral fellow in the laboratory of immunobiologist ...
Source: Massachusetts General Hospital Jan 13, 2019 7 years ago
A study from a Massachusetts General Hospital (MGH) research team has identified the specific function of a protein found in HIV and related viruses that appears to slow down viral spread in the earliest stages of infection. But they also found that, after initially slowing down the spread of infection, that function may help the virus survive later on by evading the immune response. Their report ...
Source: Pasteur Institute Jan 01, 2019 7 years ago
Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus – it is their metabolic (or energy-producing) activity1 that enables the virus to multiply. Thanks to met...
Source: Mary Ann Liebert, Inc Dec 13, 2018 7 years ago
A new study has shown that HIV-infected men had lower median bone mineral density (BMD) scores at the hip compared to HIV-uninfected men, and all men who received testosterone had significantly greater BMD scores at the lumbar spine. Further, in HIV-infected men with virologic suppression testosterone was significantly associated with a higher BMD score at the lumbar spine, as reported in AID...
Source: University Of Montreal Dec 01, 2018 7 years ago
Of the 50 million people around the world infected with HIV, less than one per cent have immune systems strong enough to suppress the virus for extended periods of time. These special immune systems are known as "elite controllers." But how do they actually fight HIV? Canadian scientists think they've found an important clue.
TRIM5 Alpha protein
Working in collaboration with a team...
Source: Johns Hopkins University Of Medicine Nov 28, 2018 7 years ago
Researchers at Johns Hopkins have identified two patients with HIV whose immune cells behave differently than others with the virus and actually appear to help control viral load even years after infection. Moreover, both patients carry large amounts of virus in infected cells, but show no viral load in blood tests. While based on small numbers, the data suggest that long-term viral remission migh...
Source: Public Library Of Science, US Nov 16, 2018 7 years ago
Mechanisms that govern HIV transcription and latency differ in the gut and blood, according to a study published November 15 in the open-access journal PLOS Pathogens by Steven Yukl of San Francisco Veterans Affairs Medical Center and the University of California, San Francisco, and colleagues. According to the authors, the findings could inform new therapies aimed at curing HIV.
HIV R...
Source: University of California Nov 01, 2018 8 years ago
Researchers are investigating other antiretrovirals, antibodies, injectables, implants, vaginal rings, vaginal films and other products
Oral pre-exposure prophylaxis (PrEP) based on tenofovir disoproxil fumarate /emtricitabine (Truvada)has set a high bar for prevention effectiveness, but a range of alternative PrEP products are in development, Raphael Landovitz of the University of...
The newest once-daily, all-in-one HIV combination pills can maintain undetectable viral load for two years and counting, according to a set of studies presented at ID Week 2018 this month in San Francisco.
Two phase 3 clinical trials showed that most people who took the bictegravir-based Biktarvy co-formulation or the doravirine-based Delstrigo pill for first-line t...
Source: Boston University School of Medicine Aug 28, 2018 8 years ago
A new study has shown that genital warts may promote HIV sexual transmission and, in turn, their treatment and prevention could help decrease the spread of the disease.
HIV infecting a human cell. Credit: NIH
Human Papillomavirus (HPV) is a common and highly infectious condition transmitted between persons during sexual skin-to-skin contact. It has more than 100 strains identified, with s...
Source: Massachusetts General Hospital, Boston Aug 08, 2018 8 years ago
Raza M. Alvi, M.D., from Massachusetts General Hospital in Boston, and colleagues compared characteristics, cardiac structure, and outcomes in 394 persons with HIV and heart failure who were receiving PI (145 patients) versus non-PI (NPI; 249 patients) therapy. PI-based antiretroviral therapy contained boosted-dose ritonavir.
Ritonavir-boosted protease inhibitor (PI) therapy is a...
Study paves way for better use of primate models in HIV vaccine development
The mosaic vaccine HIV-1 vaccine produced comparable immune responses in both humans and rhesus monkeys, a phase I/IIa trial found.
In humans, the vaccine was safe and produced antibody responses and T-cell responses, and in monkeys, the vaccine not only produced similar immune responses, but protected again...
Scientists from UNSW Sydney and the UK have discovered that the human immunodeficiency virus (HIV) hijacks a small molecule from the host cell to protect itself from being destroyed by the host's immune system.
Inositol hexakisphosphate fits into the pore structures (pink) of the HIV capsid (teal), and makes the makes the capsid stronger, protecting the genetic material inside. Credi...
Source: USFDA & Staff Writer, TMN Jul 19, 2018 8 years ago
A small percentage of patients, some of whom have taken many HIV drugs in the past, have multidrug-resistant HIV, limiting their treatment options
HIV naturally mutates and eventually develops resistance to ARVs, which are then rendered ineffective. Patients infected with drug resistant strains of HIV are therefore commonly moved to alternative regimens known as 2nd line drugs.
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People living with HIV must take a combination of three or more different drugs every day for the rest of their lives. Unfortunately, by following this strict treatment plan, they can suffer from side effects ranging from mild dizziness to life-threatening liver damage. However, if they stop taking the drugs, the virus hiding inside their cells can spontaneously resurface.
In fact...
Source: University of Edinburgh Jul 21, 2018 8 years ago
People infected with HIV are twice as likely to suffer from heart disease, research has found.
Analysis of global figures reveals that HIV-associated cardiovascular disease has more than tripled in the past 20 years as more people are living longer with the virus.
The greatest impact is in sub-Saharan Africa and Asia Pacific regions, with Swaziland, Botswana and Lesotho particularly ...
French biotech Abivax’s might be on the verge of HIV cure and prevention discovery, after achieving a significant reduction of viral load patients during the first 28 days of treatment.
The company has announced results from the first group of patients in its most recent phase 2a trial testing the potential HIV cure treatment codenamed ABX464.
The study aimed at acc...
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