HIV / AIDs - Thailand Medical News

Spread Of HIV In Human Tissues Can Be Reduced By Vesicles Secreted By Certain Bacteria Strains

Source: Thailand Medical News Dec 12, 2019 4 years ago

A study of human cells and tissues by researchers at the National Institutes of Health and the University of Bologna, Italy has shown that Nano-sized vesicles released by certain bacteria that inhabit the vagina may protect against HIV infection. Typically known as extracellular vesicles, these bubble-like particles are produced by many kinds of cells and are thought to transport molecules...

Research Indicates That Babies Born With HIV Should Start Antiretrovirals Immediately

Source: Thailand Medical News Nov 30, 2019 4 years ago

For babies are born with HIV, starting treatment within hours to days is critical and important according to a new study led by researchers from Harvard. Unfortunately the norm in many countries is to wait for weeks or even months. The study findings, from a small but unique study in Botswana, could influence care in Africa and other regions hit hard by the virus. They also might offer a ...

Scripps Research, California Releases Promising Results From Experimental HIV Vaccine

Source: Thailand Medical News Nov 25, 2019 4 years ago

Researchers at Scripps Research, California and the nonprofit vaccine research organization IAVI who are developing an experimental HIV vaccine has reached an important milestone by eliciting antibodies that can neutralize a wide variety of HIV strains. The tests, in animal models,showed that these “broadly neutralizing” antibodies, or bnAbs, targeted at least two critical sites on ...

HIV Patients And Even Doctors Not Aware Of Past Study That Links HIV With Break Down Of Intestinal Lining

Source: Thailand Medical News Nov 21, 2019 4 years ago

Despite a few past research studies that links HIV with 'erosion" of the gut's intestinal linings, leading to inflammation and also the ‘leaky gut” syndrome, many HIV patients and even doctors are not aware of this. In one past research in 2014, researchers at University of California, Davis had made some surprising discoveries about the body's initial response...

Study Shows Those With HIV Are At High Risk Of Sudden Cardiac Deaths

Source: Thailand Medical News Nov 15, 2019 5 years ago

In a study by researchers from Johns Hopkins University School of Medicine comparing medical information from portable EKG patch data from men living with HIV and also men without it, the researchers report they have found more variability of the electrical "reset" period between heartbeats known as the QT interval in men living with the virus, which may contribute to the increased...

Study Shows That Women With HIV Experience Menopause Earlier

Source: Thailand Medical News Nov 11, 2019 5 years ago

A new study demonstrates that women with HIV are more likely to enter the menopause transition at an average age of 48 years, 3 years younger than the general population. Study results are published online in Menopause, the journal of The North American Menopause Society (NAMS). Typically, newly diagnosed HIV-positive patients who adhere to the latest therapy protocols are expected to...

Breaking News: AGT103-T, New Drug By American Gene Technologies Developed To Cure HIV/AIDS Unveiled

Source: Thailand Medical News Nov 10, 2019 5 years ago

A group of medical and genomic researchers in Maryland from a company called American Gene Technologies announced that they have the answer for curing HIV/AIDS using gene therapy. The company hopes to initiate medical trials of a new gene therapy drug that it says can cure HIV. American Gene Technologies (AGT), a Rockville-based medical research company, has submitted a Investigational New...

Abbott Discovers New Strain of HIV

Source: Thailand Medical News Nov 07, 2019 5 years ago

Abbott announced today that a team of its scientists identified a new subtype of the human immunodeficiency virus (HIV), called HIV-1 Group M, subtype L.1 The findings, published today in the Journal of Acquired Immune Deficiency Syndromes (JAIDS), show the role next-generation genome sequencing is playing in helping researchers stay one step ahead of mutating viruses and avoiding n...

Tesamorelin (Egrifta) Reverses Signs of Liver Disease In Individuals With HIV

Source: Thailand Medical News Oct 26, 2019 5 years ago

Medical researchers from the US National Institutes of Health and the Massachusetts General Hospital (MGH) in Boston report that the injectable hormone tesamorelin (Egrifta) reduces liver fat and prevents liver fibrosis (scarring) in people living with HIV. Dr Anthony S. Fauci,NIAID Director (NIAID is one of the entities under the NIH) commented in a phone interview with Thailand Medical ...

Selenium Helps To Reduce HIV Viral Loads and Also Prevent CD4 Levels From Declining

Source: Thailand Medical News Oct 24, 2019 5 years ago

From 2007 to 2018, there has been more than 37 studies that show that Selenium supplementation is good for HIV patients. Selenium supplementation has demonstrated the ability to reduce viral loads of the HIV virus while also preventing CD4 levels from declining and helping it achieve moderate gains. Todate, there are been no known reactions or contraindications for those taking antiretrov...

Researchers Discover Ways To Deal With HIV Reservoirs To Create Longer Periods Of Virus Suppression And Possible Cure

Source: Thailand Medical News Oct 23, 2019 5 years ago

An new research study involving an international collaboration that included the University of Cape Town (UCT), Centre for the AIDS Program of Research in South Africa (CAPRISA) and the University of North Carolina at Chapel Hill (UNC) has revealed an unexpected finding that could lead to better therapies towards reducing the HIV reservoir, a major barrier to developing a cure for HIV. The reservo...

Descovy Approved As Second PrEP Drug To Prevent HIV Infection

Source: Thailand Medical News Oct 05, 2019 5 years ago

The US FDA has approved second PrEXp (pre-exposure prophylaxis) drug, Descovy (emtricitabine 200 mg and tenofovir alafenamide 25 mg) to help prevent HIV infections. The drug is for in at-risk adults and adolescents weighing at least 35kg for HIV-1 pre-exposure prophylaxis (PrEP) to reduce the risk of HIV-1 infection from sex, excluding those who have receptive vaginal sex. Descovy is not indicated...

Guide Of Micronutrients, Antioxidants, Health Supplements and Herbs For HIV Patients

Source: Thailand Medical News Sep 25, 2019 5 years ago

Thailand Medical News is pleased to present this simple guide with regards to essential micronutrients, health supplements and herbal products for people living with HIV. It is not mean for anyone to abstain from their prescribed antiretroviral therapies and before commencing any consumption any of these products, always consult your doctors first. Micronutrients All vitamins and minerals are ...

New duoCAR-T Therapy Study Shows Promising Future For HIV Cure

Source: Thailand Medical News Sep 24, 2019 5 years ago

CAR-T, a type of immunotherapy may have made its name as the cancer breakthrough of this century, but its roots dig far back to one of humanity’s other terrifying medical enemy: HIV. CAR-T is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then t...

Chronic Diseases That Long-Term HIV Patients Will Face

Source: Thailand Medical News Sep 23, 2019 5 years ago

Longterm patients will ultimately face increased incidence of heart disease, COPD, Tuberculosis and bone fractures according to a new study. These are the areas that HIV patients need to take extra care off besides their antiretroviral regimens. Academics from Anglia Ruskin University (ARU) in Cambridge and the Medical University of Vienna conducted the first ever large-scale review into th...

New Long-Acting Injectable Multi-Drug Implant HIV Treatment

Source: Thailand Medical News Sep 21, 2019 5 years ago

For those on Antiretroviral therapy for prevention or treatment of HIV, whether on a single pill or combo regimen, it can be burdensome making sure the drugs are consumed without fail at the right times despite having a busy daily schedule. Those days might soon be over thanks to medical researchers across multiple departments at the University of North Carolina who collaborated on a seven-y...

RV144 HIV Vaccine Trials Shows Cross Clade Immune Responses

Source: Thailand Medical News Sep 20, 2019 5 years ago

Results of a study that was conducted in South Africa using the RV144/Thai vaccine regimen that showed modest protection in an efficacy study conducted in Thailand, where clades B and E are prominent indicated significant cellular and antibody responses in study participants with clade C as the dominant circulating strain of HIV. "Trial Responses Dispels The Notion That Each Strain or Clade...

Newly Developed Protein Drug Shows Promise In Suppressing And Maybe Even Eradicating HIV Infection

Source: Thailand Medical News Aug 08, 2019 5 years ago

A new potential medication that works with an HIV-infected person's own body to further suppress the ever present but silent virus that available HIV treatments are unable to combat has been discovered by a team of medical scientist from University of Texas Medical Branch at Galveston. In an exclusive interview with Thailand Medical News, lead author Assistant Professor Haito Hu comme...

START Study Shows That Initiating ART For Individuals With Low Viral Loads Has More Benefits In The Long Term

Source: Thailand Medical News Jul 15, 2019 5 years ago

Findings from the recent START study involving 4684 adult HIV-positive patients from various countries showed that starting antiretroviral therapy (ART) has significant benefits and entails few risks for individuals with a low pre-treatment viral load. All the patients in the study had a CD4 cell count above 500 cells/mm3 and were randomised to start immediate ART or to defer therapy until th...

Discovery Of New Type of Immune Cells,CD11c+, Leads To New HIV Treatment Strategy

Source: Thailand Medical News Jun 22, 2019 5 years ago

New immunity cells known as CD11c+ dendritic cells have been identified by a team of researchers from The Westmead Institute For Medical Research in Sydney.These CD11c+ dendritic cells are extremely susceptible to the HIV virus and can transmit the virus to other cells especially the CD4 T Cells. These CD11c+ dendritic cells are a type of dendritic cells that play a role in capturing any i...

Keytruda, An Immunotherapy Drug Safe For Treating HIV Patients With Cancer

Source: Thailand Medical News Jun 04, 2019 5 years ago

Most HIV patients have a 60% risk of developing a form of cancer during their life-span. Cancers like Lymphoma, Lung Cancer, Anal Cancer, Cervical Cancer, Oral and oropharyngeal cancer ,liver cancer, skin cancer and also Kaposi's sarcoma are most prevalent among HIV patients. At the recent ASCO presentation, study led by doctors at Fred Hutchinson Cancer Research Center showed that pati...

New Strategies For HIV Vaccine

Source: La Jolla Institute for Immunology, California May 11, 2019 5 years ago

A new HIV vaccine delivery strategy appears to enhance the protective immune response in a preclinical model. Scientists at the La Jolla Institute for Immunology (LJI) have discovered that delivering an HIV vaccine in small doses over a series of days leads to a stronger immune response than when the same vaccine is given all at once. A similar escalating dose method could be the best way...

New antibody,UB-421, may suppress HIV for up to four months

Source: NIH/National Institute of Allergy and Infectious Diseases,US Apr 18, 2019 5 years ago

Regular infusions of an antibody that blocks the HIV binding site on human immune cells may have suppressed levels of HIV for up to four months in people undergoing a short-term pause in their antiretroviral therapy (ART) regimens, according to a report published online today in The New England Journal of Medicine. Results of the Phase 2, open-label study indicate the antibody, known as UB-42...

Antibiotic Cotrimoxazole found to reduce adverse effects in HIV patients.

Source: The London School of Medicine (Blizard Institute) Apr 05, 2019 5 years ago

A recent research found that long-term cotrimoxazole treatment reduces mortality and morbidity in children with HIV by altering their gut microbiome and immune activation. The finding supports current WHO guidelines, which recommend long-term cotrimoxazole treatment for all HIV-positive people living in areas where malaria and severe bacterial infections are common. Previous studies have shown...

Long-acting injectable treatment maintains HIV viral suppression.

Source: Conference on Retroviruses and Opportunistic Infections (CROI 2019) ,Seattle. Mar 10, 2019 5 years ago

A combination of two long-acting injectable anti-HIV drugs taken once monthly had a very low rate of treatment failure and a favourable safety profile, according to results from two phase III trials presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2019) in Seattle. Dual injections of cabotegravir, an experimental integrase inhibitor, and the no...

Cofilin, a T cell marker could help lead to improved treatment for HIV and also cancer patients

Source: George Mason University Feb 15, 2019 5 years ago

George Mason University's Yuntao Wu is the lead scientist on a research team that has identified a measurable indicator that could prove instrumental in the fight against HIV. The research focuses on cofilin, a key protein that regulates cells to mobilize and fight against infection. In an HIV-infected patient, cofilin dysfunction is a key factor in helper T cell defects, according to the r...

New Insights Into HIV For Possible Vaccine

Source: Simon Fraser University Feb 03, 2019 5 years ago

The immune system is the body's best defense in fighting diseases like HIV and cancer. Now, an international team of researchers is harnessing the immune system to reveal new clues that may help in efforts to produce an HIV vaccine. SFU professor Mark Brockman and co-authors from the University of KwaZulu-Natal in South Africa have identified a connection between infection cont...

‘Hidden HIV’ can now be accurately measured

Source: Howard Hughes Medical Institute Jan 31, 2019 5 years ago

Researchers can now quickly and accurately count a hidden, inactive form of the human immunodeficiency virus (HIV) that lurks in patients' cells. This version of HIV embeds into cells' genomes and can persist despite otherwise successful therapies, thwarting attempts to cure the infection. Using a new genetic technique developed by Howard Hughes Medical Institute Investigator Robert Sil...

Yale scientists examine how an immune system protein helps suppress HIV

Source: Yale University Jan 24, 2019 5 years ago

Much of the research on HIV has focused on preventing infection but little is understood about how the body keeps the virus in check post-infection. A new study by Yale investigators reveals the role of a protein that serves to block HIV gene expression once it has entered human cells. The research team, led by Manabu Taura, a postdoctoral fellow in the laboratory of immunobiologist ...

Study Of NEF Protein Released Due To HIV Infection Could Lead To New Therapeutic Developments

Source: Massachusetts General Hospital Jan 13, 2019 5 years ago

A study from a Massachusetts General Hospital (MGH) research team has identified the specific function of a protein found in HIV and related viruses that appears to slow down viral spread in the earliest stages of infection. But they also found that, after initially slowing down the spread of infection, that function may help the virus survive later on by evading the immune response. Their report ...

Targeting HIV Viral Reservoirs – The Next Frontier in the AIDS Battle.

Source: Pasteur Institute Jan 01, 2019 5 years ago

Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus – it is their metabolic (or energy-producing) activity1 that enables the virus to multiply. Thanks to met...

Study shows that Testosterone may aid HIV male patients with better BMD (bone mineral density).

Source: Mary Ann Liebert, Inc Dec 13, 2018 5 years ago

A new study has shown that HIV-infected men had lower median bone mineral density (BMD) scores at the hip compared to HIV-uninfected men, and all men who received testosterone had significantly greater BMD scores at the lumbar spine. Further, in HIV-infected men with virologic suppression testosterone was significantly associated with a higher BMD score at the lumbar spine, as reported in AID...

TRIM5-alpha plays an important role in the HIV fight.

Source: University Of Montreal Dec 01, 2018 5 years ago

Of the 50 million people around the world infected with HIV, less than one per cent have immune systems strong enough to suppress the virus for extended periods of time. These special immune systems are known as "elite controllers." But how do they actually fight HIV? Canadian scientists think they've found an important clue. TRIM5 Alpha protein Working in collaboration with a team...

Study shows that manipulating CD8 T cell behavior is the key to HIV Suppression In the infected.

Source: Johns Hopkins University Of Medicine Nov 28, 2018 5 years ago

Researchers at Johns Hopkins have identified two patients with HIV whose immune cells behave differently than others with the virus and actually appear to help control viral load even years after infection. Moreover, both patients carry large amounts of virus in infected cells, but show no viral load in blood tests. While based on small numbers, the data suggest that long-term viral remission migh...

HIV latency in the various body tissues varies.

Source: Public Library Of Science, US Nov 16, 2018 6 years ago

Mechanisms that govern HIV transcription and latency differ in the gut and blood, according to a study published November 15 in the open-access journal PLOS Pathogens by Steven Yukl of San Francisco Veterans Affairs Medical Center and the University of California, San Francisco, and colleagues. According to the authors, the findings could inform new therapies aimed at curing HIV. HIV R...

Future Trends In PrEP, moving beyond Truvada.

Source: University of California Nov 01, 2018 6 years ago

Researchers are investigating other antiretrovirals, antibodies, injectables, implants, vaginal rings, vaginal films and other products Oral pre-exposure prophylaxis (PrEP) based on tenofovir disoproxil fumarate /emtricitabine (Truvada)has set a high bar for prevention effectiveness, but a range of alternative PrEP products are in development, Raphael Landovitz of the University of...

New single-tablet regimens show long-term effectiveness in HIV management according to studies.

Source: IDWeek2018 Oct 25, 2018 6 years ago

The newest once-daily, all-in-one HIV combination pills can maintain undetectable viral load for two years and counting, according to a set of studies presented at ID Week 2018 this month in San Francisco. Two phase 3 clinical trials showed that most people who took the bictegravir-based Biktarvy co-formulation or the doravirine-based Delstrigo pill for first-line t...

Risk of HIV transmission increased by untreated Genital Warts

Source: Boston University School of Medicine Aug 28, 2018 6 years ago

A new study has shown that genital warts may promote HIV sexual transmission and, in turn, their treatment and prevention could help decrease the spread of the disease. HIV infecting a human cell. Credit: NIH Human Papillomavirus (HPV) is a common and highly infectious condition transmitted between persons during sexual skin-to-skin contact. It has more than 100 strains identified, with s...

Danger of HIV patients increasing Heart Failure rates by using Protease inhibitors

Source: Massachusetts General Hospital, Boston Aug 08, 2018 6 years ago

Raza M. Alvi, M.D., from Massachusetts General Hospital in Boston, and colleagues compared characteristics, cardiac structure, and outcomes in 394 persons with HIV and heart failure who were receiving PI (145 patients) versus non-PI (NPI; 249 patients) therapy. PI-based antiretroviral therapy contained boosted-dose ritonavir. Ritonavir-boosted protease inhibitor (PI) therapy is a...

HIV Vaccine Candidate 'Defines Additional Path' for Preclinical Data

Source: The Lancet Jul 22, 2018 6 years ago

Study paves way for better use of primate models in HIV vaccine development The mosaic vaccine HIV-1 vaccine produced comparable immune responses in both humans and rhesus monkeys, a phase I/IIa trial found. In humans, the vaccine was safe and produced antibody responses and T-cell responses, and in monkeys, the vaccine not only produced similar immune responses, but protected again...

Study shows how HIV is shielded from immune attack

Source: Multiple Jul 21, 2018 6 years ago

Scientists from UNSW Sydney and the UK have discovered that the human immunodeficiency virus (HIV) hijacks a small molecule from the host cell to protect itself from being destroyed by the host's immune system. Inositol hexakisphosphate fits into the pore structures (pink) of the HIV capsid (teal), and makes the makes the capsid stronger, protecting the genetic material inside. Credi...

Trogazo approved for multidrug-resistant HIV

Source: USFDA & Staff Writer, TMN Jul 19, 2018 6 years ago

A small percentage of patients, some of whom have taken many HIV drugs in the past, have multidrug-resistant HIV, limiting their treatment options HIV naturally mutates and eventually develops resistance to ARVs, which are then rendered ineffective. Patients infected with drug resistant strains of HIV are therefore commonly moved to alternative regimens known as 2nd line drugs. &n...

Lessons from Cancer drug that reactivates HIV can possibly lead to a new approach in HIV Cure

Source: Multiple Jul 18, 2018 6 years ago

People living with HIV must take a combination of three or more different drugs every day for the rest of their lives. Unfortunately, by following this strict treatment plan, they can suffer from side effects ranging from mild dizziness to life-threatening liver damage. However, if they stop taking the drugs, the virus hiding inside their cells can spontaneously resurface. In fact...

HIV infection doubles risk of heart disease, global study finds

Source: University of Edinburgh Jul 21, 2018 6 years ago

People infected with HIV are twice as likely to suffer from heart disease, research has found. Analysis of global figures reveals that HIV-associated cardiovascular disease has more than tripled in the past 20 years as more people are living longer with the virus. The greatest impact is in sub-Saharan Africa and Asia Pacific regions, with Swaziland, Botswana and Lesotho particularly ...

Study indicates potential breakthrough HIV drug

Staff Writer, TMN Jul 05, 2018 6 years ago

French biotech Abivax’s might be on the verge of HIV cure and prevention discovery, after achieving a significant reduction of viral load patients during the first 28 days of treatment. The company has announced results from the first group of patients in its most recent phase 2a trial testing the potential HIV cure treatment codenamed ABX464. The study aimed at acc...

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