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Source: Thailand Medical News  Jul 16, 2019  4 years, 9 months, 1 week, 3 days, 16 hours, 59 minutes ago

Mobility Limitation And Disability In The Aged Caused By Low Vitamin K Levels

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Mobility Limitation And Disability In The Aged Caused By Low Vitamin K Levels
Source: Thailand Medical News  Jul 16, 2019  4 years, 9 months, 1 week, 3 days, 16 hours, 59 minutes ago
Researchers from Tuff University’s Jean Mayer USDA Human Nutrition Research Center have discovered that  low levels of circulating vitamin K are linked to increased risk of mobility limitation and disability in older adults. The first to evaluate the association between biomarkers of vitamin K status and the onset of mobility limitation and disability the elderly.



Kyla Shea, a nutrition scientists and lead author commented in an interview with Thailand Medical News, "Because of our increasing population of older people, it is essential for us to understand the variety of risk factors for mobility disability. Low vitamin K status has been associated with the onset of chronic diseases that lead to disability, but the work to understand this connection is in its infancy. Previous studies found that low levels of circulating vitamin K are associated with slower gait speed and a higher risk of osteoarthritis."

In this new study, the researchers studied two biomarkers: circulating levels of vitamin K (phylloquinone) and a functional measure of vitamin K (plasma ucMGP). Using patient data from the Health, Aging, and Body Composition Study (Health ABC), the study found that older adults with low levels of circulating vitamin K were more likely to develop mobility limitation and disability. The other biomarker, plasma ucMGP, did not show clear correlations with mobility limitation and disability.

Older adults (both males and females) with low circulating vitamin K levels were nearly 1.5 times more likely to develop mobility limitation and nearly twice as likely to develop mobility disability compared to those with sufficient levels.

The researchers used data from 635 male patients and 688 female patients aged between 70 to 79 years. In Health ABC, mobility was assessed every half a year for six to ten years through annual clinic visits and phone interviews. For the present analysis, the researchers defined mobility limitation as two consecutive semi-annual reports of having any amount of difficulty either with walking a quarter of a mile or climbing 10 steps without resting, and mobility disability as two consecutive semi-annual reports of having a lot of difficulty or inability to walk or climb the same amount.

Circulating vitamin K levels reflect the amount of vitamin K in the diet or from supplements. The best food sources of vitamin K include leafy greens such as spinach, kale and broccoli and some dairy products. For an average adult, one cup of raw spinach provides 145 micrograms (mcg) of vitamin K1, or 181 percent of the Daily Value; one cup of raw kale provides 113 mcg, or 141 percent; and half of a cup of chopped boiled broccoli provides 110 mcg, or 138 percent.

Reference: M Kyla Shea, Stephen B Kritchevsky, Richard F Loeser, Sarah L Booth. Vitamin K Status and Mobility Limitation and Disability in Older Adults: The Health, Aging, and Body Composition Study. The Journals of Gerontology: Series A, 2019; DOI: 10.1093/gerona/glz108

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