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Source: COVID-19  Oct 07, 2020  3 years, 6 months, 1 week, 4 days, 20 hours, 30 minutes ago

COVID-19: German Autopsy Study Of 43 Deceased COVID-19 Patients Reveals Shocking Findings Of How SARS-CoV-2 Virus Directly Damages The Brains

COVID-19: German Autopsy Study Of 43 Deceased COVID-19 Patients Reveals Shocking Findings Of How SARS-CoV-2 Virus Directly Damages The Brains
Source: COVID-19  Oct 07, 2020  3 years, 6 months, 1 week, 4 days, 20 hours, 30 minutes ago
COVID-19: German researchers from the University Medical Center, Hamburg-Eppendorf and University of Freiburg in a new detailed autopsy study involving 43 deceased COVID-19 patients have discovered shocking findings as to how the SARS-CoV-2 coronavirus ‘literally attacks’ the human host brains.


 
In the early stages of the pandemic, numerous researchers made claims that the SARS-CoV-2 could not cross the brain barrier and that the brains were safe from the virus. Then as neurological symptoms started to become more apparent, some later came up with the hypothesis that it was the cytokine storms that were affecting the brains and the central nervous system.
 
It was only about late May that smaller studies showed proof that the SARS-CoV-2 coronavirus was able to infiltrate the Central Nervous System and also directly attack the human host’s brain.
 
However this autopsy study involving 43 deceased patients showed a degree of consistency as to how the SARS-CoV-2 coronavirus attacks the brains over a short period of time.
 
Most of the patients died in hospitals, nursing homes, or at home, and were aged between 51 years and 94 years (median 76 years [IQR 70–86]).
 
The study team detected fresh territorial ischaemic lesions in six (14%) patients. 37 (86%) patients had astrogliosis in all assessed regions. Activation of microglia and infiltration by cytotoxic T lymphocytes was most pronounced in the brainstem and cerebellum, and meningeal cytotoxic T lymphocyte infiltration was seen in 34 (79%) patients. SARS-CoV-2 could be detected in the brains of 21 (53%) of 40 examined patients, with SARS-CoV-2 viral proteins found in cranial nerves originating from the lower brainstem and in isolated cells of the brainstem.
 
Interestingly the presence of SARS-CoV-2 in the CNS was not associated with the severity of neuropathological changes which implies that while the brain is under attack by the SARS-CoV-2 coronavirus, individuals or doctors might not be able to know till in a late stage of damage.
 
The study findings were published in the journal: Lancet Neurology