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Source: Thailand Medical News  Jan 23, 2020  4 years, 2 months, 3 weeks, 6 days, 8 hours, 22 minutes ago

HIV Breakthrough: Researchers Reverse HIV Latency Paving Way For Potential Cure

HIV Breakthrough: Researchers Reverse HIV Latency Paving Way For Potential Cure
Source: Thailand Medical News  Jan 23, 2020  4 years, 2 months, 3 weeks, 6 days, 8 hours, 22 minutes ago
More than 42 million people are infected with HIV worldwide, about 1.5 million people in the United States alone. Currently, people with HIV take antiretroviral therapy (ART), which can suppress HIV to undetectable levels in blood, but the virus persists throughout the body in latently infected resting CD4+ T cells. The immune system cannot recognize these cells and no current therapies can eliminate them. When ART is stopped, viral loads spike in blood. This is why people with HIV must take ART continuously, and this latent reservoir is considered the greatest obstacle to a cure.



Medical scientists from the University of North Carolina at Chapel Hill and Emory University have now used a compound called AZD5582 to activate latently infected CD4+ T cells at impressive levels in blood and many different tissues with no or very little toxicity.

The new research findings are published in Nature journal.

This new research findings was accomplished at the University Of North Carolina School of Medicine in ART-suppressed mouse models with fully functioning human immune cells, the kind typically infected with HIV in humans. Importantly, this research was then extended in a longitudinal, multi-dose study at Emory University in ART-suppressed rhesus macaques infected with Simian Immunodeficiency Virus (SIV). Qura Therapeutics, a partnership between scientists at UNC-Chapel Hill and ViiV Healthcare, conducted the basic science investigations that expedited the work in animal models. More research is needed before testin