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Source: Thailand Medical News  Feb 01, 2020  4 years, 2 months, 2 weeks, 4 days, 16 hours, 29 minutes ago

German Researchers Develop Less Toxic And More Effective HIV Treatment Using Broadly Neutralizing Antibodies That Also Prevent Viral Resistance

German Researchers Develop Less Toxic And More Effective HIV Treatment Using Broadly Neutralizing Antibodies That Also Prevent Viral Resistance
Source: Thailand Medical News  Feb 01, 2020  4 years, 2 months, 2 weeks, 4 days, 16 hours, 29 minutes ago
Typically antiretroviral drugs are the gold standard for the treatment of HIV infection. They are highly effective in suppressing replication of the virus but require lifelong daily application and can be associated with side effects. Due to the high mutability of HIV and its capacity for rapid adaptation, combinations of antiretroviral agents are required to prevent the development of drug resistance and treatment failure.


(L-F): Dr Henning Gruell, Dr Philipp Schommers and Dr Florian Klein. Credit: Uniklinik Koeln/Thies Schoening
 
Currently, broadly neutralizing antibodies are a focus of ongoing research on novel options for the treatment and prevention of HIV infection. Their mode of action substantially differs from regular antiretroviral drugs, as antibodies target the virus through specific binding of HIV surface proteins.
 
Recent clinical trials have demonstrated the potential of broadly neutralizing antibodies by reducing the viral load in the blood of HIV-infected individuals. Similar to antiretroviral drugs, however, the effects of single a