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BREAKING NEWS
Source: COVID-19 Diagnostics  Sep 25, 2020  1 year ago
COVID-19 Diagnostics: University Of Birmingham Develops New Inexpensive And Convenient Dried Blood Spot Antibody Test To Widen COVID-19 Testing
COVID-19 Diagnostics: University Of Birmingham Develops New Inexpensive And Convenient Dried Blood Spot Antibody Test To Widen COVID-19 Testing
Source: COVID-19 Diagnostics  Sep 25, 2020  1 year ago
COVID-19 Diagnostics: Immunology experts at the University of Birmingham-UK have developed a new COVID-19 test using dried blood spot samples (DBS) as an accurate alternative to venous blood in detecting SARS-CoV-2 antibodies.


DBS sampling is simple, inexpensive and can be self-collected by
the patient at home, using a simple finger prick.
Credit: University Of Birmingham

 
The research findings are published in the journal: Emerging Infectious Diseases, a journal of the U.S. CDC.
https://wwwnc.cdc.gov/eid/article/26/12/20-3309_article
 
At present antibody testing for COVID-19 uses serum or plasma, which requires a full intravenous blood sample, collected by a trained phlebotomist.
 
However for population-wide or high volume testing, the use of such sampling is limited by logistic challenges, resources, and costs, as well as the risk of SARS-CoV-2 exposure from direct patient contact.
 
The dried blood spot (DBS) sampling in contrast, is simple, inexpensive and can be self-collected by the patient at home, using a simple finger prick. The sample can then be collected on a forensic grade card before being posted back to labs for processing.
 
Such a platform offers exciting possibilities to widen access to antibody testing particularly in more resource limited countries.
 
The study team analyzed serum and dried blood spot (DBS) samples from volunteers at University Hospitals Birmingham Foundation NHS Trust, some of whom had previously tested positive for SARS-CoV-2 by molecular tests, while the status of other volunteers was either negative or unknown.
 
The anonymized matched serum and DBS samples were then processed using a highly sensitive ELISA test, developed by the University’s Clinical Immunology Service in partnership with The Binding Site, which specifically detects antibodies (IgG, IgA and IgM) to the SARS-CoV-2 trimeric spike protein.
 
The Binding Site is a company that specializes in diagnostics reagents and assays. https://www.bindingsite.com/en
 
The University’s Clinical Immunology Service provides diagnostic services to the public, government agencies and private entities. https://www.birmingham.ac.uk/facilities/clinical-immunology-services/immunology-services/diagnostic-services/index.aspx
 
The study findings showed a significant correlation between matched DBS and serum samples and minimal differences in results observed by sample type, with negligible discordance. Relative to serum samples, DBS samples achieved 98% sensitivity and 100% specificity for detecting anti-SARS-CoV-2 S glycoprotein antibodies. 100% of the PCR-positive samples were also antibod y-positive in DBS.
 
Dr Matthew O’Shea from the University’s Institute of Immunology and Immunotherapy  who is also the senior author told Thailand Medical News, “Our study results have demonstrated that dry blood spot sampling not only offers a viable alternative for antibodies testing, but one that overcomes the limitations that current methods can present by eliminating the need for skilled phlebotomists.”
 
Co-author Professor Adam Cunningham from the Institute of Immunology and Immunotherapy further added, “DBS offers the opportunity for wider population-level testing and improved surveillance in vulnerable groups such as patients with chronic conditions, the immunocompromised, and the elderly by removing the need to come into contact with a health care professional during sample collection.”
 
He further added, “As well as offering the opportunity for improved population-wide antibody testing in the UK, the simplicity and cost-effectiveness of the dry blood spot method could improve the effectiveness of sampling in low and middle-income countries, among groups where venepuncture is culturally unacceptable or in geographically dispersed populations.”
 
For more on the latest in COVID-19 Diagnostics, keep on logging to Thailand Medical News.
 
 

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Feb 05, 2020  2 years ago
Source : Thailand Medical news

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