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Source: Thailand Medical News  Dec 17, 2020  3 years, 4 months, 2 days, 58 minutes ago

Washington University Study Shows That Surface Proteins On SARS-CoV-2 Virus Modifies Expression Of Key Cytokines And Chemokines In Cell Lines

Washington University Study Shows That Surface Proteins On SARS-CoV-2 Virus Modifies Expression Of Key Cytokines And Chemokines In Cell Lines
Source: Thailand Medical News  Dec 17, 2020  3 years, 4 months, 2 days, 58 minutes ago
A new study by researchers from Washington University School of Medicine- Saint Louis, Missouri has found that the surface proteins on sars-cov-2 virus modifies expression of key cytokines and chemokines in cell lines, inducing induce interferon-dependent inflammation.


 
According to the study team, SARS-CoV-2, the virus that has caused the COVID-19 pandemic, robustly activates the host immune system in critically ill patients. Understanding how the virus engages the immune system will facilitate the development of needed therapeutic strategies.
 
The study team demonstrates both in vitro and in vivo that the SARS-CoV-2 surface proteins Spike (S) and Envelope (E) activate the key immune signaling interferon (IFN) pathway in both immune and epithelial cells independent of viral infection and replication. These proteins induce reactive oxidative species generation and increases in human and murine specific IFN-responsive cytokines and chemokines, similar to their upregulation in critically ill COVID-19 patients. Induction of IFN signaling is dependent on canonical but discrepant inflammatory signaling mediators as the activation induced by S is dependent on IRF3, TBK1, and MYD88 while that of E is largely MYD88 independent. Furthermore, these viral surface proteins, specifica