Nikhil Prasad Fact checked by:Thailand Medical News Team Dec 27, 2025 1 hour, 54 minutes ago
Medical News: A Fresh Look at a Deadly Condition
Sepsis is a life-threatening condition that happens when the body overreacts to an infection and starts damaging its own organs. Despite modern medicine, sepsis remains one of the leading causes of death worldwide. Scientists are still trying to understand why the body’s immune system goes into overdrive and how this process can be controlled safely and effectively.
Common allergy and steroid drugs may work together to calm deadly immune reactions in sepsis
In a newly published experimental study, researchers explored whether two commonly used medicines cetirizine an antihistamine and dexamethasone a steroid could help calm this dangerous immune response. This
Medical News report highlights how the study uncovered new insights into inflammation control and a potential new biomarker linked to sepsis severity.
Who Conducted the Study
The research was carried out by scientists from multiple institutions including Ankara University Faculty of Veterinary Medicine, Firat University Medical School and Faculty of Veterinary Medicine, Erzincan Binali Yildirim University Medical School, Samsun Gazi State Hospital, and Kookmin University in South Korea. The wide collaboration added strength and depth to the findings.
How the Study Was Done
The researchers used a well-established laboratory model of sepsis in rats that closely mimics how severe infection spreads in the human body. The animals were divided into several groups including healthy controls untreated sepsis and sepsis treated with cetirizine dexamethasone or a combination of both. Blood and tissue samples were examined within 16 hours to track inflammation immune cell changes and organ damage.
Key Findings Explained Simply
In untreated sepsis animals the immune system became extremely aggressive. White blood cells especially neutrophils surged while protective lymphocytes dropped. At the same time harmful inflammatory messengers such as TNF alpha and several interleukins rose sharply. These changes are known to drive organ injury and failure.
One of the most important discoveries was the sharp drop in a protective molecule called Maresin 1. This substance normally helps the body switch off inflammation and begin healing. Lower Maresin 1 levels were strongly linked to higher inflammation and worse liver damage.
When cetirizine or dexamethasone was given the immune response became more balanced. Inflammation markers dropped immune cell levels improved and Maresin 1 levels rose again. The most impressive results were seen when both drugs were used together showing reduced liver injury and more controlled immune activity.
Why This Matters
The study suggests that Maresin 1 could become an early warning signal for sepsis severity and progression. Even more importantly it shows that combining an antihistamine with a steroid may help calm the immune storm without completely shutting down the body&
;rsquo;s defenses.
Conclusion
Overall, the findings suggest that cetirizine and dexamethasone especially when used together can significantly reduce harmful inflammation restore immune balance and protect organs during sepsis. The discovery of Maresin 1 as a key marker also opens the door for earlier diagnosis and better monitoring of treatment response. These results may eventually help guide safer and more effective therapies for sepsis patients.
The study findings were published in the peer reviewed Journal of Clinical Medicine.
https://www.mdpi.com/2077-0383/15/1/198
For the latest on sepsis, keep on logging to Thailand
Medical News.
Read Also:
https://www.thailandmedical.news/articles/sepsis
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