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Source: Medical News-CD19-SARS-CoV-2  Nov 10, 2021  2 years, 5 months, 1 week, 8 hours, 48 minutes ago

Study Alarmingly Reveals That SARS-CoV-2 Infection Causes Immunodeficiency In Recovered Patients By Downregulating CD19 Expression In B Cells!

Study Alarmingly Reveals That SARS-CoV-2 Infection Causes Immunodeficiency In Recovered Patients By Downregulating CD19 Expression In B Cells!
Source: Medical News-CD19-SARS-CoV-2  Nov 10, 2021  2 years, 5 months, 1 week, 8 hours, 48 minutes ago
A new multi-country  research by scientist from Huazhong University of Science and Technology, Wuhan-China, Third Hospital of Shanxi Medical University, Taiyuan-China, Wuhan Institute of Virology-Chinese Academy of Sciences-China, Karolinska Institute-Sweden,  Universidad Autónoma de Chile, University of Ulsan College of Medicine, Seoul-Korea,  RIKEN Yokohama Institute, Kanagawa-Japan, The University of Hong Kong and Yangtze University, Jingzhou-China has alarmingly found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism!

 
It is already known that the SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients.
 
In this new research, the study team characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation.
 
However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation.
 
Shockingly, the study findings revealed that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation.
 
Mechanistically, the study team found that the reduced CD19 expression was caused by the dysregulation of cell metabolism.
 
The study findings confirmed that that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.
 
The study findings were published in the peer reviewed journal: Signal Transduction And Targeted Therapy (Nature)
https://www.nature.com/articles/s41392-021-00749-3
 
Numerous past studies have shown that the SARS-CoV-2 infection causes has caused immune disruption in a variety of ways.
 
Studies have reported that COVID-19 patients had decreased lymphocyte counts and increased counts of myeloid cells in peripheral blood. https://www.nature.com/articles/s41421-020-0168-9
 
https://jamanetwork.com/journals/jama/article-abstract/2761044
 
Many recent reports show lymphopenia with drastically reduced numbers of both CD4+ and CD8+ T cells in moderate and severe COVID-19 cases.
https://jamanetwork.com/journals/jamanetworkopen/article-abstract/2766670
 
https://academic.oup.com/jid/article/221/11/1762/5813618?login=true
 
F low cytometry analysis of PBMCs from symptomatic COVID-19 patients has shown a significant influx of granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing, activated CD4+ T cells and CD14+ HLA-DRlo inflammatory monocytes (IMs). https://www.sciencedirect.com/science/article/pii/S1931312820302365
 
https://academic.oup.com/nsr/articl