Herbs And Phytochemicals: Extracts From Rhizomes Of Atractylodes Macrocephala Koidz (Baizu) Can Help In Gastric Cancer
Kittisak Meepoon Fact checked by:Thailand Medical News Team Mar 27, 2024 4 weeks, 2 days, 21 hours, 43 minutes ago
Herbs And Phytochemicals: Gastric cancer remains a significant global health challenge, ranking as the fifth most common cancer worldwide. Its prognosis is often poor due to challenges in early detection and treatment, resulting in substantial pain, financial burdens, and social impact for patients and their families. As the focus shifts towards enhancing the quality of life and improving cancer prevention and early intervention strategies, there is a growing interest in exploring alternative therapies, including herbal medicine.
Extracts From Rhizomes Of The Herb Atractylodes Macrocephala Koidz
(Baizu) Can Help In Gastric Cancer
One such herbal remedy with potential anti-cancer properties is Atractylodes macrocephala Koidz (AMK), a traditional East Asian medicine used for centuries to address various ailments, including cancers. In this
Herbs And Phytochemicals news report, we delve into the scientific exploration of AMK extract's effects on gastric cancer, drawing insights from studies conducted at prestigious institutions like Pusan National University School of Korean Medicine, Daegu Catholic University School of Medicine, Korea Food Research Institute, and Korea University of Science & Technology in South Korea.
Understanding Atractylodes macrocephala Koidz (AMK) - Historical Significance and Traditional Uses
AMK, known as Baegchul in Korea and Báizhú in China, has a rich historical background in traditional Korean, Japanese, and Chinese medicine. It has been utilized to treat a spectrum of conditions, including gastrointestinal disorders, spleen dysfunction, appetite loss, and various digestive issues. Its efficacy in addressing chronic ailments like indigestion, diarrhea, and fatigue has made it a staple in herbal medicine formulations.
Network-Based Pharmacological Analysis
To unravel AMK's potential in gastric cancer therapy, the study team employed a network-based systems pharmacology approach. Leveraging the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, they identified 18 active compounds from AMK that met stringent ADME (absorption, distribution, metabolism, excretion) criteria.
These compounds, including GLY, LPG, ASI, D-Serin, and others, exhibited interactions with 260 target genes associated with diverse cellular pathways.
Furthermore, the study revealed 37 AMK phytochemicals linked to gastrointestinal (GI) cancer, highlighting the herb's specific relevance to gastric cancer treatment. Notably, compounds like atractylenolide I, atractylenolide III, and palmitic acid showed direct associations with critical gastric cancer-related genes such as TNF, IL6, BCL2, PTEN, CTNNB1, and SRC.
Experimental Insights into AMK's Anti-Cancer Mechanisms In Vitro Experiments
-Cytotoxicity and Cell Cycle Arrest: AMK extract demonstrated concentration-dependent cytotoxic effects on AGS human gastric aden
ocarcinoma cells. Notably, it induced G1 phase cell cycle arrest, a characteristic feature of anti-cancer agents.
-Apoptosis Induction: AMK extract triggered apoptosis in AGS cells through mitochondrial pathway activation, as evidenced by increased ROS production, alterations in mitochondrial membrane potential, and activation of caspases involved in intrinsic apoptotic pathways.
-Modulation of Signaling Pathways: AMK extract influenced key signaling pathways such as MAPK (mitogen-activated protein kinase), leading to reduced cell proliferation and migration capabilities of AGS cells.
-Inhibition of Tumor Growth: In a 3D spheroid model mimicking tumor growth, AMK extract significantly suppressed spheroid formation, further validating its anti-cancer potential.
In Vivo Experiments
In mouse xenograft models of human gastric adenocarcinoma, AMK extract administration resulted in a notable reduction in tumor growth without significant adverse effects on body weight, highlighting its efficacy and safety profile in vivo.
Discussion and Conclusions
The comprehensive investigation into AMK's anti-cancer effects sheds light on its promising therapeutic potential for gastric cancer treatment. Through network pharmacological analysis, identification of active compounds, and in-depth mechanistic studies, researchers have elucidated the intricate pathways through which AMK extract exerts its anti-cancer effects.
Noteworthy findings include AMK's ability to induce apoptosis, inhibit cell proliferation and migration, modulate signaling pathways, and suppress tumor growth both in vitro and in vivo. These multifaceted actions underscore AMK extract as a novel and multifunctional therapeutic agent against gastric adenocarcinoma.
In conclusion, the study paves the way for further research into AMK's detailed mechanisms, clinical applications, and potential integration into mainstream cancer therapies. With continued exploration and validation, AMK extract holds promise as a valuable addition to the armamentarium of treatments for gastric cancer, offering hope for improved outcomes and enhanced quality of life for patients battling this challenging disease.
The study findings were published in the peer reviewed journal: Nutrients.
https://www.mdpi.com/2072-6643/16/7/965
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