COVID-19 News – Bivalent Boosters Jun 15, 2023 10 months, 1 week, 4 days, 23 hours, 48 minutes ago
Study Questions Efficacy Of Bivalent Boosters As Omicron Variants Continue to Puzzle Experts
COVID-19 News: Cleveland Clinic, one of the leading medical institutions in the United States, has conducted a groundbreaking study that might leave you in stitches. In an unexpected turn of events, their research revealed that individuals who were "not up-to-date" on their COVID-19 vaccinations, as defined by the Centers for Disease Control and Prevention (CDC), had a lower risk of infection. Yes, you read that right - being out of the vaccination loop seemed to provide a shield against the notorious virus!
The study, conducted by experts from the Cleveland Clinic aimed to compare the risk of COVID-19 between those considered "up-to-date" and those who were not. The CDC defines individuals as "up-to-date" if they have received at least one dose of a COVID-19 bivalent vaccine, leaving the not-so-vaccinated crowd in the "not up-to-date" category.
Amidst the emergence of new Omicron variants and recombinant sub-lineages that display increased immune evasion, doubts have been cast on the efficacy of bivalent boosters. These doubts prompted the Cleveland Clinic researchers to question whether being "up-to-date" with a vaccine of inconclusive effectiveness truly offered protection against COVID-19, especially compared to those who remained "not up-to-date."
The study involved employees of the Cleveland Clinic who were working when the COVID-19 bivalent vaccine was first introduced and were still employed when the dominant XBB lineages emerged. Out of the 48,344 employees included in the study, 1475 (3%) contracted COVID-19 during the 100-day observation period. Interestingly, the cumulative incidence of COVID-19 was significantly lower in the "not up-to-date" group compared to the "up-to-date" group.
Even after adjusting for various factors like age, sex, and propensity to get tested for COVID-19, the researchers found that individuals who were "not up-to-date" had a lower risk of contracting the virus. The study's multivariable analysis revealed that not being "up-to-date" with COVID-19 vaccination was associated with a reduced risk of COVID-19 (HR, 0.77; 95% C.I., 0.69-0.86; P-value <0.001).
These unexpected results raise important questions about the effectiveness of the bivalent vaccine, particularly against the XBB lineages of the Omicron variant.
Additionally, the study suggests that the CDC's definition of being "up-to-date" overlooks the potential protective effects of immunity acquired from prior infection. It seems like Mother Nature might have some tricks up her sleeve!
Past
COVID-19 News coverages had also showed doubts about the efficacy of the bivalent boosters that are still being promoted and advocated by lots of health authorities around the world!
id-19-news-beth-israel-deaconess-medical-center-study-shows-that-xbb-1-5-variant-escapes-neutralizing-antibody-responses-after-bivalent-mrna-boosti">https://www.thailandmedical.news/news/covid-19-news-beth-israel-deaconess-medical-center-study-shows-that-xbb-1-5-variant-escapes-neutralizing-antibody-responses-after-bivalent-mrna-boosti
https://www.thailandmedical.news/news/covid-19-news-study-published-in-peer-reviewed-journal-shows-that-repetitive-boosters-cause-humoral-and-cellular-immune-tolerance-in-mice
https://www.thailandmedical.news/news/covid-19-news-are-all-these-antibodies-elicited-by-various-jabs-and-boosters-and-frequent-sars-cov-2-infections-really-safe-for-the-human-body
https://www.thailandmedical.news/news/breaking-covid-19-news-study-warns-that-frequent-boosters-may-cause-humoral-immune-tolerance-and-inhibit-the-activation-of-cd8-t-cells
https://www.thailandmedical.news/news/covid-19-news-hybrid-immunity-and-bivalent-boosters-have-little-effect-on-new-omicron-sub-lineages-bq-1-1-and-ba-2-75-2-due-to-immune-imprinting
https://www.thailandmedical.news/news/breaking-german-study-finds-that-healthcare-workers-receiving-new-bivalent-jabs-experience-more-adverse-effects-than-monovalent-booster
https://www.thailandmedical.news/news/breaking-cambridge-study-claims-that-booster-shots-in-the-aged-leads-to-impaired-sars-cov-2-neutralization,-impaired-t-cells-and-also-atypical-b-cells
https://www.thailandmedical.news/news/public-healthcare-in-germany-collapses-as-many-vaccinated-doctors-and-nurses-are-falling-sick-due-to-sars-cov-2-ba-5-infections
https://www.thailandmedical.news/news/latest-study-published-in-the-lancet-shows-that-boosters-shots-of-mrna-vaccines-do-not-prevent-omicron-breakthrough-infections
While this new study adds a comedic twist to the ongoing vaccination debates, it's essential to consider its limitations. The research focused on all detected infections and did not differentiate between asymptomatic and symptomatic cases. It's possible that some milder infections went unnoticed, leading to incomplete information on prior COVID-19 history. Moreover, the study population skewed younger, preventing a thorough examination of how the vaccine performs in immunocompromised individuals.
Despite these limitations, the study's large sample size and real-time assessment of vaccine efficacy make it an important addition to the ongoing conversation. The findings challenge our understanding of vaccine protection and highlight the need for further research and a nuanced approach to defining vaccination status.
As we navigate the ever-evolving landscape of COVID-19, this study reminds us that science can be full of surprises, even when it comes to something as serious as a global pandemic. It reminds us not to take things at face value and encourages us to dig deeper into the complexities of vaccine effectiveness.
The study findings were published on a preprint server and are currently being peer reviewed.
https://www.medrxiv.org/content/10.1101/2023.06.09.23290893v1
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