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Source: Supplements For COVID-19  Aug 13, 2020  3 years, 8 months, 4 days, 16 hours, 43 minutes ago

BREAKING! Supplements For COVID-19: Quercetin Emerging As An Adjuvant For COVID-19 Treatments

BREAKING! Supplements For COVID-19: Quercetin Emerging As An Adjuvant For COVID-19 Treatments
Source: Supplements For COVID-19  Aug 13, 2020  3 years, 8 months, 4 days, 16 hours, 43 minutes ago
Supplements For COVID-19: Quercetin-a common plant based supplement is being viewed by some as a potential adjunct therapy for patients with COVID-19. Medical professionals who support the use of the supplement say it could be one part of a treatment regimen along with interventions like remdesivir or convalescent plasma, and that its over-the-counter availability and relatively good safety profile serve as advantages.


 
Quercetin is a pigment found in many fruits, vegetables, and plants. Quercetin belongs to a family of bioflavonoids, responsible for the bright colours and medicinal properties of many plants. You can get Quercetin through a balanced diet or as a food supplement. Foods and drinks that contain Quercetin include berries, apples, citrus fruits, kale, tomatoes, onions, buckwheat, red wine, and black tea. It is also found in herbal remedies, such as ginkgo biloba and St John's wort. Quercetin can be taken as a supplement in addition to other products. It can act as an antioxidant, neutralising free radicals that cause cellular and DNA damage. Quercetin is known for its antibacterial and anti-inflammation properties, ability to prevent neurological diseases, and lower high blood pressure.
 
Significantly it has been found that quercetin promotes SIRT2, which then inhibits the NLRP3 inflammasome assembly involved with COVID-19 infection, said Dr Samuel F. Yanuck, DC, of the Program on Integrative Medicine at the University of North Carolina Chapel Hill School of Medicine, who co-authored a review of emerging research on the subject. It also plays a role in facilitating zinc transportation across lipid membranes, Dr Yanuck said. https://imjournal.com/oa/evidence_supporting-a_phased_immuno-physiological_approach_to_covid-19_from_prevention_through_recovery/
 
Dr Yanuck told Thailand Medical News, "It's not a bizarre or experimental substance and given it has these potential important biological roles, I think it's worth being considered as part of an overall strategy. Quercetin would need to be one part of a multifactorial treatment regimen.”
 
It was found that in cell cultures, quercetin has been shown to prevent viral entry and reduce the cytopathic effects of many viruses, including rhinovirus and poliovirus. In a 2016 animal study, rodents administered quercetin before being exposed to a lethal load of Ebola virus survived. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997876/
 
Significantly, COVID-19 has been associated with high levels of interleukin-6, depleted levels of interferons, and a cytokine storm that damages the body and is related to respiratory failure, said Dr Ruben Colunga Biancatelli, MD, of Old Dominion University in Norfolk, Virginia, and first author of a paper on quercetin and vitamin C as a potential therapy for treating SARS-CoV-2 in Frontiers in Immunology. https://www.frontiersin.org/articles/10 .3389/fimmu.2020.01451/full
 
Researchers are also suggesting that vitamin C should be administered with quercetin because it can recycle oxidized quercetin, producing a synergistic effect and enhancing quercetin's antiviral capability.
 
Interestingly during  the 2003 SARS outbreak, Chinese researchers found that quercetin bound to the spike protein of the virus, interfering with its ability to replicate and infect host cells.