GREAT NEWS! Preliminary Data Shows That SARS-CoV-2 BA.2.12.1 And BA.4 Variants Have RO Of 15 Similar To Measles And Also Unique Pathogenesis!
Emerging data from South Africa and also from the United States is showing that the new SARS-CoV-2 BA.2 subvariant ie BA.2.12.1
and the new BA.4
variant has a RO number of 15, implying that it is just as contagious as measles if not more.
Both variants are now spreading globally but the BA.2.12.1
variant is fast becoming the dominant variant in the United States and is expected to supersede the BA.2 variant in days.
variant is already starting the fifth wave in South Africa with daily infection raising exponentially and causing ‘mild hospitalizations’ and ‘mild’ deaths! (Note we are being sarcastic here as some of the stupid South African experts who are under the payroll of the big pharma companies often like spew garbage like all Omicron infections were mild or that the current COVID-19 jabs still work well etc!) In reality, the BA.4
variant is worst than the original Wuhan wildtype strain and seems to be causing severe ARD issues with many developing hypoxia and requiring ventilators along with ICU care as what is being witnessed in South Africa currently.
What is worrying is that both variants are able to cause breakthrough infections and also reinfections even in people who were previously exposed to the BA.1 variant or BA.2 variant. (studies on non-protection from BA.2 infection induced immunity will be published shorthly).
Both variants also contain the L452R or L452Q mutations which are known to promote cell fusion, often resulting in disease severity! https://www.thailandmedical.news/news/warning-more-ba-2-subvariants-with-the-concerning-mutations-l452q-or-l452r-that-increases-fusogenicity-and-infectivity-are-emerging-and-spreading-glob
Both variants have as shorter incubation period or between only 2 to 3 days and it was found that viral loads in the lungs and even blood rises extremely fast upon infection!
For those with existing comorbidities or are aged and also the young and those with immunosuppressed issues, these variants can be deadly and for the rest, although they might only have mild symptoms upon infection, these new variants are expected to cause far more serious Long COVID issues!
To make matters worse, preliminary studies are also showing that because of the large number of mutations found in these new variants including missense mutations in the Mpro section of the ORF1a/b gene, many current Mpro inhibitors or antivirals currently being used are totally obsolete against these new variants especially the B.4
While countries in the West the United States and many countries in Europe are trying to ignore the coming problems and are relaxing measures and concealing the potential seriousness, the next few surges are expected to be catastrophic not only due to the these variants but because of how the kinetics of the current pandemic will lead to more re-infections, co-infections and the eventual rise of more lethal variants and subvariants.
The BA.2 and B.4
should have been designated as separate variants of concern (VOC) and not lumped as Omicron variants as they are very diverse from the original BA.1 variant and contain far much more different mutations.
What is concerning is that despite some stupid researchers coming out with fake data claiming that the BA.2 and BA.4
variant is not mutating as rapidly as the influenza virus, in reality the truth is that both are spawning many concerning subvariants and even third generation subvariants very rapidly as they fight to overcome both natural immunity and vaccine induced immunity and also the effects of various therapeutics and antivirals.
It will be fun in coming weeks to see if this is all merely fear porn as some stupids like to claim or whether many of these stupids will end up dying!
For more on the BA.2.12.1 and BA.4 variants
, keep on logging to Thailand Medical News.