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Source: COVID-19 Supplements  Aug 05, 2020  1 year ago
COVID-19 Supplements: Yet Another Research In Lancet Advocating Vitamin D For COVID-19 While Another Study Proposes Using Vitamin D As A Prophylaxis
COVID-19 Supplements: Yet Another Research In Lancet Advocating Vitamin D For COVID-19 While Another Study Proposes Using Vitamin D As A Prophylaxis
Source: COVID-19 Supplements  Aug 05, 2020  1 year ago
COVID-19 Supplements: There is growing mounting evidence of the usage of Vitamin D to prevent severity of COVID-19 disease and now even as a prophylaxis to lower the risk of even contracting COVID-19.


 
The latest report published in the journal: Lancet by researchers from the London School Of Medicine and Dentistry -Queen Mary University Of London and School Of Clinical Medicine-University of Cambridge postulates that vitamin D favorably modulates host responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), both in the early viraemic and later hyperinflammatory phases of COVID-19. Vitamin D metabolites have long been known to support innate antiviral effector mechanisms, including induction of antimicrobial peptides and autophagy.
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30268-0/fulltext#%20
 
Numerous studies of using Vitamin D to deal with various aspects of COVID-19 has been emerging the last few months despite initial attempts by unscrupulous doctors and certain researchers who are under payroll of large pharmaceutical companies to claim that Vitamin D had no effects of any kind on the COVID-19 disease.
 
In this new report, the researchers discussed the possibility that vitamin D could offer protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Based on the meta-analyses of randomized controlled trials performed from 2007 to 2020, the results revealed that vitamin D does have protective effects against acute respiratory infections.
 
The study observed that the risk factors for severe COVID-19 are akin to those of vitamin D deficiency. These include obesity, older age, and Black or Asian ethnic origin. They hypothesized that supplementation with vitamin D could become protective, preventive, or therapeutic against COVID-19.

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The researchers said there are reasons why vitamin D induces host responses to SARS-CoV-2, early on in the infection, and in the latter stages of the illness.
 
Past studies have shown that vitamin D supports the body’s natural antiviral effector mechanisms, such as antimicrobial peptides and autophagy. (Antimicrobial peptides or AMPs, also known as host defense peptides, are short positively charged peptides that can kill microbial pathogens directly while autophagy, also known as “self-eating,” is the body’s process of cleaning out damaged cells to regenerate healthier ones.)
 
The researchers wrote that laboratory data showing the effects of Vitamin D on host response to the novel coronavirus are scarce. However, one study had shown that when the scientists screened four compound libraries for antiviral activity, they found that vitamin D’s active metabolite, 1,25-dihydroxyvitamin D, has an inhibitory effec t in human epithelial cells that are infected with SARS-CoV-2.
 
The vitamin has shown to help regulate immunopathological inflammatory responses in respiratory infections.
 
Past research investigated the link between circulating levels of 25-hydroxyvitamin D (25(OH)D), which is a biomarker of vitamin D status of the body, and the incidence and severity of SARS-CoV-2 infection.
 
Also two other studies have shown inverse relationships between national estimates of vitamin D levels or status and the incidence of COVID-19, including the mortality in European countries.
 
The research has shown that when there are lower concentrations of 25(OH)D, the risk or susceptibility to COVID-19 increases. Also, the study revealed that COVID-19 severity increases when there are low levels of Vitamin D in the body.
 
Interestingly, airway diseases are tied to dysregulated vitamin D metabolism, increasing the possibility that vitamin D deficiency may become a complication of inflammation in the respiratory tract.
 
There are studies that highlight the potential for reverse causality, which means that low levels of vitamin D may lead to a higher incidence and severity of COVID-19.
 
The study team researchers noted that further studies are needed, involving well-powered randomized controlled trials of vitamin D supplementation in preventing and treating COVID-19 patients.
 
In yet another study, a team of researchers claimed that calcitriol exhibits significant potent activity against SARS-CoV-2, paving the way for the development of host-directed therapies for ring prophylaxis of contacts of COVID-19 patients. https://www.biorxiv.org/content/10.1101/2020.06.21.162396v1
 
The report enlightened on the use of vitamin D on COVID-19 patients. Many hospital-based treatment trials have been registered, which focused on vitamin D supplementation in severe COVID-19.
 
As an example, another study suggested that vitamin D supplementation has been proven to be safe and has helped reduce the risk of acute respiratory infection (ARI), which is the initial infection seen in most COVID-19 patients. https://www.medrxiv.org/content/10.1101/2020.07.14.20152728v1
 
However, more research is needed to see the benefits of vitamin D supplementation in reducing the risk of severe COVID-19.
 
The study team recommends taking vitamin D supplements since there is nothing to lose when taking them, and might even be more beneficial since vitamin D has many other health benefits.
 
Read Also: https://www.thailandmedical.news/news/covid-19-supplements-israeli-study-confirms-that-vitamin-d-critical-in-covid-19-as-low-plasma-level-of-it-is-a-risk-factor-for-sars-cov-2-infection
 
And: https://www.thailandmedical.news/news/covid-19-supplements-new-study-shows-vitamin-d-could-be-linked-to-covid-19-mortality-and-infection-rates
 
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