COVID-19 Supplements: Israeli Study Confirms That Vitamin D Critical In COVID-19 As Low Plasma Level Of It Is A Risk Factor For SARS-CoV-2 Infection
: A new Israeli research has again confirmed that Vitamin D plays a very important role in the COVID-19 disease. In this new research it was found that low Vitamin D levels in blood plasma was a risk factor for contracting the COVID-19 disease.
The research findings were published in The FEBS Journal. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15495
It should be noted that when Thailand Medical News first highlighted the merits of Vitamin D in COVID-19 management in late April and early May, we were met by criticisms and even labeled as misinformation by numerous ignorant and stupid individuals and entities. Certain American medical journals, news sites and social media platforms paid by pharma giants even went on to discredit the initial research and article.https://www.thailandmedical.news/news/covid-19-supplements-new-study-shows-vitamin-d-could-be-linked-to-covid-19-mortality-and-infection-rates
However since then more studies have merged to support and confirm that Vitamin D plays a critical role in the COVID-19 disease. https://www.thailandmedical.news/news/covid-19-supplements-vitamin-d-could-help-in-a-supporting-role-to-treat-covid-19-confirms-new-research-involving-10-international-medical-institutions
Typically, vitamin D is recognized as an important co-factor in several physiological processes linked with bone and calcium metabolism, and also in diverse non-skeletal outcomes, including autoimmune diseases, cardiovascular diseases, type 2 diabetes, obesity and cognitive decline, and infections. In particular, the pronounced impact of vitamin D metabolites on the immune system response, and on the development of COVID-19 infection by the novel SARS CoV-2 virus, has been previously described in a few studies worldwide.
The new research led by Israeli scientists from the Leumit Health Services (LHS) and the Azrieli Faculty of Medicine of Bar-Ilan University aimed to determine associations of low plasma 25(OH)D with the risk of COVID-19 infection and hospitalization.
Utilizing the real-world data and Israeli cohort of 782 COVID-19 positive patients and 7,025 COVID-19 negative patients, the groups identified that low plasma vitamin D level appears to be an independent risk factor for COVID-19 infection and hospitalization.
Dr Eugene Merzon, Head of the Department of Managed Car
e and leading researcher of the LHS group told Thailand Medical News, "The main finding of our study was the significant association of low plasma vitamin D level with the likelihood of COVID-19 infection among patients who were tested for COVID-19, even after adjustment for age, gender, socio-economic status and chronic, mental and physical disorders."
He added, "Furthermore, low vitamin D level was associated with the risk of hospitalization due to COVID-19 infection, although this association wasn't significant after adjustment for other confounders.”
Dr Ilan Green, Head of the LHS Research Institute said, "Our finding is in agreement with the results of previous studies in the field. Reduced risk of acute respiratory tract infection following vitamin D supplementation has been reported."
Dr Milana Frenkel-Morgenstern, the leader of the Azrieli Faculty of Medicine research group said, "According to our analysis, persons that were COVID-19 positive were older than non-infected persons. Interestingly, the two-peak distributions for age groups were demonstrated to confer increased risk for COVID-19: around ages 25 and 50 years old. The first peak may be explained by high social gathering habits at the young age. The peak at age 50 years may be explained by continued social habits, in conjunction with various chronic diseases.”
“Interestingly, chronic medical conditions, like dementia, cardiovascular disease, and chronic lung disease that were considered to be very risky in previous studies, were not found as increasing the rate of infection in our study. However, this finding is highly biased by the severe social contacts restrictions that were imposed on all the population during the COVID-19 outbreak. Therefore, we assume that following the Israeli Ministry of Health instructions, patients with chronic medical conditions significantly reduced their social contacts. This might indeed minimize the risk of COVID-19 infection in that group of patients, "said Prof. Shlomo Vinker, LHS Chief Medical Officer.
Both Dr Dmitry Tworowski and Dr Alessandro Gorohovski from the Frenkel-Morgenstern laboratory at Bar-Ilan University's Azrieli Faculty of Medicine, suggest that the study will have a very significant impact.
They explained, "The main strength of our study is its being large, real-world, and population-based."
The researchers are next planning to evaluate factors associated with mortality due to COVID-19 in Israel.
Dr Eugene Merzon, "We are willing to find associations to the COVID-19 clinical outcomes (for example, pre-infection glycemic control of COVID-19 patients) to make the assessment of mortality risk due to COVID-19 infection in Israel."
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