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Source: Latest COVID-19 Research  Nov 28, 2020  3 years, 4 months, 2 weeks, 6 days, 5 hours, 58 minutes ago

Latest COVID-19 Israel Research Shows That SARS-CoV-2 Utilizes A Multipronged Attack To Paralyze Human Host Protein Synthesis

Latest COVID-19 Israel Research Shows That SARS-CoV-2 Utilizes A Multipronged Attack To Paralyze Human Host Protein Synthesis
Source: Latest COVID-19 Research  Nov 28, 2020  3 years, 4 months, 2 weeks, 6 days, 5 hours, 58 minutes ago
Latest COVID-19 Research: Israeli scientists from the Weizmann Institute of Science, Rehovot-Israel and the Israel Institute for Biological Research, Ness Ziona-Israel have uncovered new details that show that the SARS-CoV-2 coronavirus deploys a multipronged strategy to suppress the mechanism of human host protein synthesis that often leads to disease progression or even to long term COVID-19 effects.


 
To date researchers still do not have a complete perspective and still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis and its ability to antagonize innate immune responses.
 
In this study, the researchers use RNA-sequencing and ribosome profiling along SARS-CoV-2 infection and comprehensively define the mechanisms that are utilized by SARS-CoV-2 to shutoff cellular protein synthesis.
 
The study team shows that SARS-CoV-2 infection leads to a total reduction in translation but that viral transcripts are not preferentially translated. Instead, the team reveals that infection leads to accelerated degradation of cytosolic cellular mRNAs which facilitates viral takeover of the mRNA pool in infected cells.
 
Furthermore the study team shows that the translation of transcripts whose expression is induced in response to infection, including innate immune genes, is impaired, implying infection prevents newly transcribed cellular mRNAs from accessing the ribosomes.
 
Overall, the study findings uncover the multipronged strategy employed by SARS-CoV-2 to commandeer the translation machinery and to suppress host defenses.
 
The research findings are published on a preprint server but are currently being peer reviewed. https://www.biorxiv.org/content/10.1101/2020.11.25.398578v1

In the case of SARS-CoV-2, interferon response seems to play a critical role in pathogenesis. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008737
 
https://www.nature.com/articles/d41586-020-03070-1
 
https://pubmed.ncbi.nlm.nih.gov/32661059/
 
https://pubmed.ncbi.nlm.nih.gov/32972996/
 
In addition, the extent to which SARS-CoV-2 suppresses the IFN response is a key characteristic that distinguishes it from other respiratory viruses.
https://pubmed.ncbi.nlm.nih.gov/32416070/
 
https://www.x-mol.com/paper/1260106673524244480
 
The new study thro