BREAKING! COVID-19 Latest: Contrary To Popular Belief, SARS-CoV-2 Does Not Trigger A Strong Immune Reaction Rather It Causes Dysfunctional Immune Issues
: A new German study is proofing that contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction, rather, the immune response is caught in a continuous loop of activation and inhibition.
Medical and immunology experts from Charité - Universitätsmedizin Berlin, the University of Bonn, the German Center for Neurodegenerative Diseases (DZNE), the Helmholtz Centre for Infection Research (HZI) and the German Center for Infection Research (DZIF), along with other researchers from a nationwide research network, presented these findings in the scientific journal Cell
Typically most patients infected with the coronavirus SARS-CoV-2 show mild or even no symptoms.
Statistically however, about 10 to 20 percent of those affected develop pneumonia during the course of COVID-19 disease, some of them with life-threatening effects.
Dr Joachim Schultze, Professor at the University of Bonn and research group leader at the DZNE told Thailand Medical News, "There is still not very much known about the causes of these severe courses of the disease. The high inflammation levels measured in those affected actually indicate a strong immune response. Clinical findings, however, rather tend to indicate an ineffective immune response. This is a contradiction.”
Dr Leif Erik Sander, Professor of Infection Immunology and Senior Physician Charité's Medical Department, Division of Infectious Diseases and Respiratory Medicine added, “We therefore assume that although immune cells are produced in large quantities, their function is defective. That is why we examined the blood of patients with varying degrees of COVID-19 severity."
The research was carried out within the framework of a nationwide consortium ie the "German COVID-19 OMICS Initiative" (DeCOI) resulting in the analysis and interpretation of the data being spread across various teams and sites. Dr Joachim Schultze was significantly involved in coordinating the project. The blood samples came from a total of 53 men and women with COVID-19 from Berlin and Bonn, whose course of disease was classified as mild or severe according to the World Health Organization classification. Blood samples from patients with other viral respiratory tract infections as well as from healthy individuals served as important controls.
The clinical investigations involved the use of single-cell OMICs technologies, a collective term for modern laboratory methods that can be used to determine, for example, the gene activity and the amount of proteins on the level of single, individual cells thus with very high resolution.
Utilizing this data, the researchers characterized the properties of immune cells circulating in the blood ie so-called white blood cells.
Dr Yang Li, Professor at the Centre for Individuali
zed Infection Medicine (CiiM) and Helmholtz Centre for Infection Research (HZI) in Hannover explained, "By applying bioinformatics methods on this extremely comprehensive data collection of the gene activity of each individual cell, we could gain a comprehensive insight of the ongoing processes in the white blood cells.”
Dr Birgit Sawitzki, Professor at the Institute of Medical Immunology on Campus Virchow-Klinikum added, "In combination with the observation of important proteins on the surface of immune cells, we were able to decipher the changes in the immune system of patients with COVID-19."
Typically, the human immune system comprises a broad arsenal of cells and other defense mechanisms that interact with each other.
For the resarch, the focus was on so-called myeloid cells, which include neutrophils and monocytes. These are immune cells that are at the very front of the immune response chain, i.e. they are mobilized at a very early stage to defend against infections. They also influence the later formation of antibodies and other cells that contribute to immunity. This gives the myeloid cells a key position.
Dr Antoine-Emmanuel Saliba, head of a research group at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg explained, "With the so-called neutrophils and the monocytes we have found that these immune cells are activated, i.e. ready to defend the patient against COVID-19 in the case of mild disease courses. They are also programmed to activate the rest of the immune system. This ultimately leads to an effective immune response against the virus."
Dr Sawitzki further explained, “But the situation is different in severe cases of COVID-19. Here, neutrophils and monocytes are only partially activated and they do not function properly. We find considerably more immature cells that have a rather inhibitory effect on the immune response."
Dr Sander adds, "The phenomenon can also be observed in other severe infections, although the reason for this is unclear. Many indications suggest that the immune system stands in its own way during severe courses of COVID-19. This could possibly lead to an insufficient immune response against the corona virus, with a simultaneous severe inflammation in the lung tissue."
The research findings could point to new therapeutic options, says Dr Anna Aschenbrenner from the LIMES Institute at the University of Bonn.
She said, "Our data suggest that in severe cases of COVID-19, strategies should be considered that go beyond the treatment of other viral diseases." The Bonn researcher says that in the case of viral infections one does not actually want to suppress the immune system.
She further stressed, "If, however, there are too many dysfunctional immune cells, as our study shows, then one would very much like to suppress or reprogram such cells."
Professor at the Medical Clinic I of the University Hospital Bonn and head of a research group at the DZIF, Dr Jacob Nattermann, further explains, "Drugs that act on the immune system might be able to help. But this is a delicate balancing act. After all, it's not a matter of shutting down the immune system completely, but only those cells that slow down themselves, so to speak. In this case these are the immature cells. Possibly we can learn from cancer research. There is experience with therapies that target these cells."
Dr Schultze emphasized the cooperation within the research consortium, "As far as we know, this study is one of the most comprehensive studies to date on the immune response in COVID-19 based on single cell data. The parallel analysis of two independent patient cohorts is one of the strengths of our study. We analyzed patient cohorts from two different sites using different methods and were thus able to validate our findings directly. This is only possible if research data is openly shared and cooperation is based on trust. This is extremely important, especially in the current crisis situation."
The new research findings has tremendous implications as many treatment protocols currently being deployed could be actually worsening the conditions in COVID-19 patients, not treating or helping them! Also the concept of cytokine storms as a result of an overdrive in the immune system could be a total fallacy.
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