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Source: COVID-19 Latest  Nov 17, 2020  3 years, 5 months, 1 day, 15 hours, 6 minutes ago

COVID-19 Latest Study Shows SARS-CoV-2 Impairs Immune System Including Causing T-Cell Lymphopenia But Increases IL‐10‐Producing Regulatory T Cells

COVID-19 Latest Study Shows SARS-CoV-2 Impairs Immune System Including Causing T-Cell Lymphopenia But Increases IL‐10‐Producing Regulatory T Cells
Source: COVID-19 Latest  Nov 17, 2020  3 years, 5 months, 1 day, 15 hours, 6 minutes ago
COVID-19 Latest: Scientists and immunologists from the VIB Research Center-Belgium, University of Leuven-Belgium and the The Babraham Institute, Cambridge-UK have in a new study that besides confirming what was already revealed in earlier studies that the SARS-CoV-2 not only impairs the human host immune system and causes T-cell Lymphopenia, has now also discovered that the infection causes an increase in  IL‐10‐Producing Regulatory T Cells that possess anti‐inflammatory properties in the lung and contributes to severe COVID-19.


 
The pandemic spread of the SARS‐CoV‐2 coronavirus is due, in part, to the immunological properties of the host–virus interaction. The clinical presentation varies from individual to individual, with asymptomatic carriers, mild‐to‐moderate‐presenting patients and severely affected patients. Variation in immune response to SARS‐CoV‐2 may underlie this clinical variation.
 
Utilizing a high‐dimensional systems immunology platform, the study team has analyzed the peripheral blood compartment of 6 healthy individuals, 23 mild‐to‐moderate and 20 severe COVID‐19 patients.
 
The team identified distinct immunological signatures in the peripheral blood of the mild‐to‐moderate and severe COVID‐19 patients, including T‐cell lymphopenia, more consistent with peripheral hypo‐ than hyper‐immune activation. Unique to the severe COVID‐19 cases was a large increase in the proportion of IL‐10‐secreting regulatory T cells, a lineage known to possess anti‐inflammatory properties in the lung.
 
As IL‐10‐secreting regulatory T cells are known to possess anti‐inflammatory properties in the lung, their proportional increase could contribute to a more severe COVID‐19 phenotype.
 
The study findings were published in the peer reviewed journal: Clinical & Translational Immunology. https://onlinelibrary.wiley.com/doi/10.1002/cti2.1204
 
The study findings adds to the developing picture of the immune system response and our understanding of the immunological features associated with the development of severe and life-threatening disease following COVID-19.
 
This detailed understanding is crucial to guide the development of effective healthcare and 'early-warning' systems to identify and treat those at risk of a severe response.
 
To date one of the most puzzling questions about the global COVID-19 pandemic is why individuals show such a diverse response. Some individuals do not show any symptoms, termed 'silent spreaders', whereas some COVID-19 patients require intensive care support as their immune response becomes extreme.
 
It is known that age and underlying health conditions are known to increase the risk of a severe response but the underlying reasons for the hyperactive immune response seen in some individuals are unexplained, although likely to be due to many factors contributing