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Source: Thailand Medical News  Nov 20, 2019  4 years, 4 months, 3 weeks, 6 days, 15 hours, 46 minutes ago

Emerging Studies Link Antibiotics With Increase the Risk of Arthritis

Emerging Studies Link Antibiotics With Increase the Risk of Arthritis
Source: Thailand Medical News  Nov 20, 2019  4 years, 4 months, 3 weeks, 6 days, 15 hours, 46 minutes ago
Rheumatoid arthritis (RA) is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels. An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body's tissues. The condition is characterized by pain and stiff joints.



Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity. Another typical feature of this disorder is the presence of autoantibodies in the serum and synovial fluid. Synovial fluid is the fluid that lubricates the synovial joints.

The detailed mechanism by which patients develop rheumatoid arthritis is unknown; however, a combination of genetic and environmental factors is likely. Autoimmune antibody production is proposed to be the main mechanism responsible for bone and joint destruction, and the related rheumatoid arthritis pathology. Infections, hormonal alterations, and stress are some potential triggers of rheumatoid arthritis.

Emerging research suggests an association between antibiotic use, gut microbiota changes, and rheumatoid arthritis flares.

Typically, antibiotics are widely used for the treatment of bacterial infections associated with the respiratory system, gastrointestinal system, and urinary tract. Although antibiotics act against pathogenic bacteria, they can also modify the normal gut microbiota.

The human gut microbiota is a diverse system of microorganisms residing in the gastrointestinal tract of the human body. Gut microbiota plays a vital role in maintaining the body’s digestive health. Gut microbiota is also involved in the immune system and the synthesis of vitamin B and vitamin K.

Many  new  epidemiological studies have demonstrated associations between the occurrence of bacterial infections and rheumatoid arthritis. Furthermore, microbiome alterations have been indicated as a potential mechanism for the effect of infection in  rheumatoid arthritis pathogenesis. Antibiotics substantially disturb the gut microbiome, with studies demonstrating significant microbial shifts in the gastrointestinal tract following their use.

The drastic alterations in the gut microbiome may last up to a year after treatment periods of only one week. As per a recent study by Nagra et al., the risk of rheumatoid arthritis flare was significantly increased in the 1–12 months after commencing treatment on sulphonamide and trimethoprim antibiotics.

Thailand  Medical News has come across new research suggests that infections are potential risk factors for