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Source: Coronavirus News  Feb 05, 2021  3 years, 2 months, 1 week, 6 days, 15 hours, 15 minutes ago

Coronavirus News: German Study Confirms That SARS-CoV-2 Coronavirus Can Invade And Damage The Liver

Coronavirus News: German Study Confirms That SARS-CoV-2 Coronavirus Can Invade And Damage The Liver
Source: Coronavirus News  Feb 05, 2021  3 years, 2 months, 1 week, 6 days, 15 hours, 15 minutes ago
Coronavirus News: A new study by researchers from University of Bielefeld-Germany, the University Medical Center Hamburg-Eppendorf-Germany and also Harvard Medical School-USA has confirmed that the SARS-CoV-2 coronavirus can invade and damage the liver.

The study findings were published in the peer reviewed journal: Clinical Gastroenterology and Hepatology.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844358/
 
SARS-CoV-2 is known to infect the nasopharynx and lungs and causes COVID-19. It may impact the heart, brain, kidney and liver. https://www.nejm.org/doi/full/10.1056/NEJMc2011400
 
Although functional impairment of the liver has been correlated with worse clinical outcomes, little is known about the pathophysiology of hepatic injury and repair in COVID-19. Histological evaluation has been limited to small numbers of COVID-19 cases with no controls and demonstrated largely heterogeneous patterns of pathology. https://www.nature.com/articles/s41379-020-00649-x
 
https://pubmed.ncbi.nlm.nih.gov/33332624/
 
https://www.thelancet.com/pdfs/journals/eclinm/PIIS2589-5370%2820%2930178-4.pdf
 
Liver tissues of 60 patients who died of COVID-19 pneumonia were obtained from complete autopsies performed in Hamburg between March and June 2020. A cohort of 13 patients with fatal pneumonia in the absence of SARS-CoV-2 infection served as controls. Hematoxylin and eosin staining and immunohistochemistry were applied to comprehensively evaluate the pathophysiology and regeneration aspects at the level of the hepatic microarchitecture. Label-free coherent-Raman-scattering- and second-harmonic-generation-imaging visualized major morphological changes, revealing steatosis and dilatation of sinusoid.
 
The study found that there were no significant differences in the patient characteristics except for pre-existing neurological conditions (p=0.04). Only 5 patients with COVID-19 and 1 control had history of liver disease. A minority of patients in the COVID-19-group (17%) received intensive care at the time of death wit