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Source: Thailand Medical News  Jan 25, 2020  4 years, 2 months, 3 weeks, 7 hours, 16 minutes ago

"Bad" Gut Microbiome Linked To Polycystic Ovary Syndrome And Obesity In Teenagers

"Bad" Gut Microbiome Linked To Polycystic Ovary Syndrome And Obesity In Teenagers
Source: Thailand Medical News  Jan 25, 2020  4 years, 2 months, 3 weeks, 7 hours, 16 minutes ago
According to a new research by medical professionals from the Children’s Hospital Colorado in Aurora, teenagers with obesity and polycystic ovary syndrome (PCOS) have more “unhealthy or bad ” gut bacteria, suggesting the microbiome may play a role in the disorder.



The research findings was published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

Polycystic ovary syndrome or PCOS is complicated endocrine disorder affecting 6 percent to 18 percent of women of reproductive age and work in adult women indicates that changes in bacteria be involved. The hormone disorder is characterized by elevated testosterone levels in the blood that cause acne, excess hair growth and irregular periods. Teenagers with polycystic ovary syndrome often also struggle with obesity and have a higher risk for type 2 diabetes, infertility, and depression.

The study’s corresponding author, Dr Melanie Cree Green, M.D., Ph.D., of Children’s Hospital Colorado in Aurora told Thailand Medical News, “We found that in adolescents with polycystic ovary syndrome and obesity, the bacterial profile (microbiome) from stool has more ‘unhealthy’ bacteria compared to teenagers without PCOS. The unhealthy bacteria related to higher testosterone concentrations and markers of metabolic complications.”

The medical researchers studied 58 teens with obesity and found that girls with polycystic ovary syndrome have an altered gut microbiome compared to those without the condition. These girls had more “unhealthy” bacteria in their stool which was related to higher testosterone levels and other markers of metabolic syndrome, such as higher blood pressure, liver inflammation and plasma triglycerides.

Dr Green added, “The gut microbiome may play a role in polycystic ovary syndrome and its related metabolic complications, and these changes can be found in teenagers who are early in the course of the condition.”

Reference : Jobira et al. (2020) Obese adolescents with PCOS have altered biodiversity and relative abundance in gastrointestinal microbiota. Journal of Clinical Endocrinology & Metabolism. DOI: https://doi.org/10.1210/clinem/dgz263