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Source: Prostate Cancer News  Jan 26, 2021  12 months ago
Prostate Cancer News: Korean Researchers Develop Faster and Accurate Urine Based Diagnostic Platform For Detecting Prostate Cancer
Prostate Cancer News: Korean Researchers Develop Faster and Accurate Urine Based Diagnostic Platform For Detecting Prostate Cancer
Source: Prostate Cancer News  Jan 26, 2021  12 months ago
Prostate Cancer News: Researchers from the the Korea Institute of Science and Technology (KIST) and the University of Ulsan College of Medicine,-Seoul have developed a new urine based diagnostic platform that far more faster and accurate to detect prostate cancer.


 
Currently screening for prostate cancer relies on the serum prostate-specific antigen test, which provides a high rate of false positives (80%).
 
Often this results in a large number of unnecessary biopsies and subsequent overtreatment. Considering the frequency of the test, there is a critical unmet need of precision screening for prostate cancer.
 
The Korean researchers introduced a urinary multimarker biosensor with a capacity to learn to achieve this goal. The correlation of clinical state with the sensing signals from urinary multimarkers was analyzed by two common machine learning algorithms. As the number of biomarkers was increased, both algorithms provided a monotonic increase in screening performance. Under the best combination of biomarkers, the machine learning algorithms screened prostate cancer patients with more than 99% accuracy using 76 urine specimens. Urinary multimarker biosensor leveraged by machine learning analysis can be an important strategy of precision screening for cancers using a drop of bodily fluid.
 
The study findings were published in the peer reviewed ACS Nano (Journal of the American Chemical Society. https://pubs.acs.org/doi/10.1021/acsnano.0c06946
 
At present prostate cancer remains as one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pains.
 
KIST or the Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr Kwan Hyi Lee from the Biomaterials Research Center and Professor Dr In Gab Jeong from Asan Medical Center at the University of Ulsan College of Medicine developed a technique for diagnosing prostate cancer from urine within only twenty minutes with almost 100% accuracy.
 
The study team developed this technique by introducing a smart AI analysis method to an electrical-signal-based ultrasensitive biosensor.
 
Significantly as a noninvasive method, a diagnostic test utilizing urine is convenient for patients and does not need invasive biopsy, thereby diagnosing cancer without side effects. However, as the concentration of cancer factors is low in urine, a urine-based biosensor has been utilized for classifying risk groups rather than for precise diagnosis thus far.
 
The study team at the KIST has been working toward developing a technique for diagnosing disease from urine by utilizing the electrical-signal-based ultrasensitive biosensor. An approach utilizing a single cancer factor associated with a cancer diagnosis was limited in increasing the diagnosis accuracy to over 90%. However, to overcome this limitation, the team simultaneously utilized different kinds of cancer factors instead of using only one to enhance the diagnostic accuracy innovatively .
 
The Korean researchers developed an ultrasensitive semiconductor sensor system capable of simultaneously measuring trace amounts of selected four cancer factors in urine for diagnosing prostate cancer. They trained AI by using the correlation between the four cancer factors, which were obtained from the developed sensor. The trained AI algorithm was then used to identify those with prostate cancer by analyzing complex patterns of the detected signals.
 
Importantly the diagnosis of prostate cancer by utilizing the AI analysis successfully detected 76 urinary samples with almost 100 percent accuracy.
 
Professor Dr In Gab Jeong from Asan Medical Center told Thailand Medical News, “For patients who need surgery and/or treatments, cancer will be diagnosed with high accuracy by utilizing urine to minimize unnecessary biopsy and treatments, which can dramatically reduce medical costs and medical staff's fatigue. This research developed a smart biosensor that can rapidly diagnose prostate cancer with almost 100 percent accuracy only through a urine test, and it can be further utilized in the precise diagnoses of other cancers using a urine test."
 
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