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Source: COVID-19 Supplements  Apr 10, 2020  11 months ago
COVID-19 Supplements: Australian Researchers Start First Clinical Trial To Test Effects Of Intravenous Zinc In COVID-19 Patients
COVID-19 Supplements: Australian Researchers Start First Clinical Trial To Test Effects Of Intravenous Zinc In COVID-19 Patients
Source: COVID-19 Supplements  Apr 10, 2020  11 months ago
COVID-19 Supplements: The first clinical trial in the world trial will see researchers from Austin Health Teaching Hospital and the University of Melbourne use intravenous zinc to fight the symptoms of COVID-19 in infected patients.


 
The clinical trial will be led by Dr Joseph Ischia from Austin Health, along with Dr Oneel Patel from the Department of Surgery at the University of Melbourne, who has a long history of investigating the protective effects of intravenous zinc against organ damage induced by lack of oxygen.
 
The researchers said that COVID-19 is especially dangerous because it replicates inside a patient's body extremely fast and can lead to respiratory conditions like bronchitis and pneumonia along with a host f emerging complications as more studies are emerging about what the SARS-CoV-2 virus is able to do inside the human body.
 
Dr Ischia told Thailand Medical News, "If COVID-19 enters a patient's lungs then they often need to be placed on a ventilator to help their breathing and, in severe cases, COVID-19 can cause multiple organ failure and brain injury due to a lack of oxygen."
 
According to Dr Patel, past studies have shown that zinc is very effective at slowing the rate that similar viruses such as SARS (Severe Acute Respiratory Syndrome) and common cold (a type of coronavirus) replicate in the body.
 
Dr Patel said, "Past published studies have also shown that high doses of zinc can protect vital organs such as the heart, kidneys and liver against the damage caused by a lack of oxygen."
 
The new clinical trial has been fast-tracked to test whether receiving a daily injection of zinc chloride will benefit patients with coronavirus.
 
Dr Ischia further added, "There is currently no specific treatment available for patients who have COVID-19 and are at high risk of respiratory failure, which means this study has the potential to have an enormous positive impact on their clinical outcomes. Importantly, we hope to show that we can save lives by limiting the impact of the symptoms. We are expecting to have preliminary results of the trial available after only seven days so we will know very quickly how effective this treatment is."
 
The clinical trial is the culmination of a rapid collaboration between surgeon scientists as well as intensive care, infectious diseases and respiratory medicine doctors at Austin Health, working with the Australian pharmaceutical firm, Phebra.
 
Dr. Mal Eutick, Phebra CEO said intravenous (IV) zinc injections, manufactured at Phebra's multi-purpose sterile injectables plant in Sydney, would be used in the trial.
 
Dr Eutick commented, "Zinc has been proven to be effective in treating severe pneumonia and other viruses although not COVID-19 to date. This trial is an extraordinary opportunity to discover if IV zinc can help us respond to the current pandemic. If successful this could save lives and with this trial we should know in a short time frame. In particular, it could be very important for those high risk elderly patients and also help reduce the level of general anxiety in the community."
 
Both Dr Ischia and Dr Eutick however warned of the need to manage the risk of zinc overdose for patients.
 
Dr Ischia explained, "Zinc can be toxic and it will be carefully administered as part of the trial to ensure patients are safe."
 
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Further references:
 
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001176
 
https://www.researchgate.net/publication/47794995_Zn_Inhibits_Coronavirus_and_Arterivirus_RNA_Polymerase_Activity_In_Vitro_and_Zinc_Ionophores_Block_the_Replication_of_These_Viruses_in_Cell_Culture
 
https://www.uchealth.org/today/zinc-could-help-diminish-extent-of-covid-19/
 
https://www.bmj.com/rapid-response/2011/10/29/zinc-ions-and-fight-against-sars
 
https://www.sciencedirect.com/science/article/pii/S2211383520302999
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136164/
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807640/
 
https://www.ncbi.nlm.nih.gov/pubmed/15164319
 
https://onlinelibrary.wiley.com/doi/full/10.1111/1541-4337.12067
 
https://link.springer.com/article/10.1007/s12576-017-0571-7
 
https://www.nature.com/articles/aps201825
 
https://www.karger.com/Article/Abstract/90495
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488004/
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724376/
 
https://www.frontiersin.org/articles/10.3389/fnut.2014.00014/full
 
 

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