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Source: COVID-19 Research  Jul 05, 2021  2 years, 9 months, 2 weeks, 18 hours, 10 minutes ago

COVID-19 Research: U.S.and Netherlands Study Shows That SARS-CoV-2 Infection Induces Accumulation Of Lipids And Viral N-Proteins In Lungs Which Leads To Disease Severity

COVID-19 Research: U.S.and Netherlands Study Shows That SARS-CoV-2 Infection Induces Accumulation Of Lipids And Viral N-Proteins In Lungs Which Leads To Disease Severity
Source: COVID-19 Research  Jul 05, 2021  2 years, 9 months, 2 weeks, 18 hours, 10 minutes ago
COVID-19 Research: A new study by researchers from Amsterdam University Medical Centre-Netherlands, VU University-Netherlands and Duke University Medical Center-USA has shown that SARS-CoV-2 infection induces accumulation of lipids and viral N-proteins in lungs, leading to disease severity.

The trafficking of coronaviruses in lung of COVID-19 patients is not well understood and virus particles are difficult to find.
 
The study team visualized virus particles in SARS-CoV-2 infected cells by focusing on viral protein detection, in combination with ultrastructure. The team studied how the virus is altering the cell morphology and determined that in Vero cells, lipid filled compartments contained various viral proteins. In these cells, also membrane enclosed multi-virus bodies were visible that contain a different set of viral proteins.
 
The study team demonstrated that lipid filled compartments are viral induced compartments, as no known cellular marker such as lipid droplet or lysosomal marker