COVID-19 Drugs: Study Shows That Critical COVID-19 Patients With Lung Injury Requiring Ventilation Benefitted From Ivermectin
: An abstract study submitted by researchers from University Of Utah, Harvard Medical School and Surgisphere Corporation showed that COVID-19 patients who were critically ill with lung injury needing mechanical ventilation, benefitted from taking Ivermectin compared to other drug alternatives. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3570270
The study lead by Dr Amit Patel from University of Utah analysed registry-based study from 169 hospitals across Asia (AS), Europe (EU), Africa (AF), North (NA) and South America (SA) involving 1970 COVID-19 infected patiemts.
In the grouping of 1,970 patients, 1,609 survived hospitalization to discharge and 361 died (18.3%).
It was recorded that 52 patients (AS-7, EU-21, AF-3, NA-14, SA-7 )had received Ivermectin (150 mcg/Kg) once after mechanical ventilation was instituted. The indications for use of the drug were related to clinician preference and based on prior data on the broad antimicrobial and specifically antiviral effects of this agent. 1
Compared to 1,918 conventionally treated patients it was observed a survival benefit for ivermectin (mortality rate 18.6% vs 7.7%; HR 0.18, 95% CI (0.07-0.48), log rank (Mantel-Cox) p<0.001. The hospital length of stay was 15.7 +/- 8.1 days vs 10.9 +/- 6.1 days, p<0.001. and intensive care unit length of stay 8.2 +/- 6.2 days versus 6.0 +/- 3.9 days, p<0.001 respectively.
The researchers noted that in COVID-19 illness, critically ill patients with lung injury requiring mechanical ventilation may benefit from administration of Ivermectin.
The researchers noted a lower mortality and reduced healthcare resource use in those treated with Ivermectin.
However, the researchers warned that these observations should not be considered definitive and allow for translation of a hypothesis from bench to bedside which will require confirmation in a controlled clinical trial setting.
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