BREAKING! Neuro-COVID: Researchers Warn Of New Neurological Conditions Manifesting In COVID-19 Patients-Miller Fisher Syndrome And Polyneuritis Cranialis
: Spanish researchers from Universidad Complutense- Madrid reported two cases studies in which COVID-19 patients were manifesting new neurological conditions not witnessed before in COVID-19 patients.
One 50 year old male patient from the University Hospital “Príncipe de Asturias,” Alcalá de Henares-madrid was reported to exhibit the neurological condition known as Miller Fisher Syndrome while the other a 39 year old male from University Hospital “12 de Octubre,” Madrid was found with the neurological condition Polyneuritis Cranialis . Both only developed the conditions after being infected with the SARS-CoV-2 coronavirus and were exhibiting symptoms consistent with COVID-19 disease.
The case reports were published in the journal: Neurology https://n.neurology.org/content/95/5/e601.long
Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms are typically be preceded by a viral illness.
is a multiple cranial neuropathy In which in the majority of cases, patients displayed a combination of ocular signs (ophthalmoplegia, ptosis or pupillary changes) and bulbar signs (dysarthria or dysphagia), which were often associated with facial weakness. Unlike other GBS subtypes, weakness was frequently asymmetric.
It was already known that the SARS-CoV-2 coronavirus is able to infect the brain and CNS system and cause a multitude of neurological conditions including simple headaches, delirium, chronic fatigue etc. https://www.thailandmedical.news/news/covid-19-news-latest-study-confirms-that-sars-cov-2-is-able-to-infect-the-brain-and-cause-neurological-issues
However this is the first time of documented occurrences of Miller Fisher Syndrome And Polyneuritis Cranialis in COVID-19 patients.
The 50-year-old man presented with anosmia, ageusia, right internuclear ophthalmoparesis, right fascicular oculomotor palsy, ataxia, areflexia, albuminocytologic dissociation, and positive testing for anti-GD1b–immunoglobulin G antibody. Five days previously, he had developed a cough, malaise, headache, low back pain, and fever.
The 39-year-old man presented with ageusia, bilateral abducens palsy, areflexia, and albuminocytologic dissociation. Three days previously, he had developed diarrhea, a low-grade fever, and poor general condition. Oropharyngeal swab test for SARS-CoV-2 by qualitative real-time reverse transcriptase PCR assay was positive in both patients and negative in the CSF.
The first patient was treated with IV immunoglobulin and the second with acetaminophen. Two weeks later, both patients made a complete neurologic recovery, except for residual anosmia and ageusia in the first case.
The researchers say that these 2 cases highlight the rare occurrence of Miller Fisher syndrome and polyneuritis cranialis during the coronavirus disease 2019 (COVID-19) pandemic. These neurologic manifestations may occur because of an aberrant immune response to COVID-19.
The full clinical spectrum of neurological symptoms in patients with COVID-19 still remains to be characterized.
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