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SARS-CoV-2 Variants - XBB.1.9.1  Feb 07, 2023  2 months ago
SARS-CoV-2 Variants Updates: New More Immune Evasive And Transmissible XBB.1.9.1 Variant Spreads In Indonesia, South East Asia And Europe!
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SARS-CoV-2 Variants Updates: New More Immune Evasive And Transmissible XBB.1.9.1 Variant Spreads In Indonesia, South East Asia And Europe!
SARS-CoV-2 Variants - XBB.1.9.1  Feb 07, 2023  2 months ago
SARS-CoV-2 Variants Updates: A newly emerged sub-lineage of the XBB recombinant variant has emerged and is spreading exponentially in Indonesia and elsewhere in South East Asia and now even in the United Kingdom and parts of Europe.

The XBB.1.9.1 sub-lineage spots the spike F486P mutation, similarly to its twin XBB.1.9.2.
The XBB.1.9.1 also spots the mutations: C11956T
The advantage that XBB.1.9.1 has comes possibly from the unique mutations it has in the accessory proteins such as Orf1a:G1819S,  Orf1a:T4175I and also Orf9b:I5T (this mutation has in the past been found in multiple chronically ill related samples with BA.5.2 and BQ.1 sub-lineages!)
Preliminary data is indicating that the XBB.1.9.1 has a better growth advantage over the XBB.1.5 and other predominant variants in circulation including XBF (in Australia and parts of Europe), CH.1.1, BQ.1.1 etc and even over the various East Asian variants (ie the various BF.7, BF.5 and BA.5.2 sub-lineages!)
In Indonesia, the XBB.1.9.1 sub-lineage has reached almost 50 percent of all sequences.
It also seems to be taking off in the United Kingdom that is now seeing a new onslaught by a cluster of various new SARS-CoV-2 Variants.
It is also found in Germany.
The XBB.1.9.1 is also now found in many countries across the world.
https://nbviewer.org/github/gerstung-lab/SARS-CoV-2-International/blob/main/genomicsurveillance-int.i pynb#Check-some-fast-growing-lineages
The XBB.1.9.1 is more immune evasive than even the XBB.1.5 variant and has better viral fitness than the XBB.1.5 variant.
To date, there is no data to show as to whether the XBB.1.9.1 sub-lineage is causing disease severity or is more pathogenic.
In countries like Indonesia, there is very little testing coupled with the fact that reported COVID-19 statistics are not the least reliable.
In fact, updated statistics are only focusing on vaccine rates and it seems that there is literally no new COVID-19 cases or deaths although genomic sequences being uploaded show otherwise!
Local Indonesian news agencies are more interested in promoting news coverages that 99 percent of the population has SARS-CoV-2 antibodies which in reality have no bearing with the new more immune evasive strains circulating around!
The XBB.1.9.1 sub-lineage is expected to supersede the XBB.1.5 variant in coming weeks and while there is no clear indication about the effects of this new variant in terms of disease severity and hospitalization and the effect of boosters on this new variant, all those in the vulnerable groups ie the old, obese, those with existing comorbidities such as diabetes, hypertension, heart and kidney issues, the immunocompromised and also those with certain genetic makeups still need to take safety precautions try to self-isolate.
For more SARS-CoV-2 Variants Update, keep on logging to Thailand Medical News.


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