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Source: COVID-19 Diagnostics  Sep 28, 2020  3 years, 6 months, 2 weeks, 6 days, 14 hours, 36 minutes ago

COVID-19 Diagnostics: New Blood-Based Host Gene Expression Assay Test Accurately Identifies Viral Infection Before Symptoms Even Develop!

COVID-19 Diagnostics: New Blood-Based Host Gene Expression Assay Test Accurately Identifies Viral Infection Before Symptoms Even Develop!
Source: COVID-19 Diagnostics  Sep 28, 2020  3 years, 6 months, 2 weeks, 6 days, 14 hours, 36 minutes ago
COVID-19 Diagnostics: Researchers from Duke University Medical Center-North Carolina have identified biomarkers that accurately identify numerous viral infections across the clinical stages of disease, advancing a potential new way to guide treatment, quarantine decisions, and other clinical and public health interventions in the setting of endemic and pandemic infectious diseases.


 
The unique blood-based test uses a gene expression assay to correctly predict nine different respiratory viral infections including influenza, enterovirus, adenovirus and coronaviruses known to cause common colds. It shows the body's genes responding to a pathogen before symptoms are present. The test is also now being assessed to see possible usage in the SARS-CoV-2 context which the study team says will most probably work just as  well.
 
The initial study results showing the effectiveness of the new test on the 9 different respiratory viral infections are published in the journal: The Lancet Infectious Diseases https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30486-2/fulltext#%20
 
Dr Micah McClain, M.D., Ph.D., Associate Professor in the Department of Medicine at Duke and lead author the  study told Thailand Medical News,  "While our research was conducted prior to the COVID-19 pandemic, our data show that these biomarkers of viral infection are present and detectable before clinical disease develops and thus could form the basis of novel approaches to early identification and management of emerging viral outbreaks and pandemics.”
 
Dr McClain said additional studies are ongoing to determine the genomic markers' effectiveness in detecting SARS-CoV-2, the strain of coronavirus that causes COVID-19. Preliminary findings from those studies have been posted on a public website and the data are currently under peer review. https://www.medrxiv.org/content/10.1101/2020.07.20.20155507v1
 
The study team at the Duke Center for Applied Genomics and Precision Medicine have been working for years to develop and fine-tune tests that quickly distinguish bacterial infections from viral infections, a public health need to assure that antibiotics are properly prescribed.
 
Antibiotics are ineffective against viruses, and their improper use has fueled the rise of treatment-resistant bacteria.
 
The present research advances that work and provides a clinically applicable approach