Source: Thailand Medical News  Jan 15, 2020  3 years ago
Research Indicates That Long-Term Skin Irritation And Inflammation Increases Risk Of Tumor Growth
Research Indicates That Long-Term Skin Irritation And Inflammation Increases Risk Of Tumor Growth
Source: Thailand Medical News  Jan 15, 2020  3 years ago
A new research has shown that an antibody that usually helps defend the skin against harmful substances or infections may promote tumor growth during chronic tissue inflammation.

The skin's defenses against environmental assault can help tumors to grow when skin is exposed to chronic inflammation, finds a study in mice published in eLife.

Typically, the IgE antibody is most commonly known for its inadvertent involvement in allergic reactions, but it is commonly found in healthy skin and believed to protect against harmful substances or parasitic infections.

However, this study shows that chronic inflammation caused by repeated exposure to skin-irritating chemicals may turn this helpful defense into a harmful one. Understanding more about this process may help scientists develop ways to prevent or treat skin cancer.

Lead author Dr Mark Hayes, who was a postdoctoral scientist at Imperial's Department of Immunology and Inflammation, at the time the study was carried out told Thailand Medical News via a phone interview, "Chronic inflammation has been linked to many types of cancers, and may cause these by enabling the growth and survival of cells with cancer-causing mutations. But the exact steps in this process and the role of IgE were not previously clear."

To understand more, Dr Hayes and his colleagues looked at what happened after inflammation-causing substances were applied to the skin. They saw an increase in the amount of IgE produced and that immune cells called basophils were attracted to the skin. When the basophils were activated by IgE, they stimulated skin cells to divide and grow.

Dr Hayes added, "IgE fortifies the skin barrier defenses by promoting cell growth to thicken the surface of the skin in response to noxious stimuli. However, this response should be temporary. If it persists in the long term, it may lead to tumor growth."

The research team found that in mice with cancer-causing mutations, chronic activation of IgE caused by inflammation subverts its protective effects and supports the growth of precancerous skin cells into tumors. On the other hand, mice lacking IgE were protected from developing these tumors in response to inflammation.

However, the results of a previous study by the team showed that IgE protects mice against cancer gt;-causing substances that damage DNA. This suggests that the mechanism of tumor growth, and the role of IgE in this process, may depend on different kinds of environmental exposure.

Senior author Dr Jessica Strid, Reader in Cellular Immunology at the Department of Immunology and Inflammation, Imperial College London, also told Thailand Medical News, "Our previous and current findings reveal a strong link between IgE and cancer. But the biological consequences of IgE engagement in the skin clearly depends on the nature of the antibodies and the microenvironment in which the tumor grows."

Reference : Mark David Hayes et al. Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth, eLife (2020). DOI: 10.7554/eLife.51862


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Source : Thailand Medical news