Newer Substitutes For Bisphenol A (BPA) In Consumer Goods Even More Toxic and Can Disrupt Heart Function Easily
, newer substitutes or counterpart replacement bisphenosl
) can hinder heart
function within minutes of a single exposure, according to a new University of Guelph study.
The research is the first to show the instant effects bisphenols
) can have on the heart
Biomedical Sciences Professor Dr Glen Pyle, who conducted the study with former master's student Dr Melissa Ferguson told Thailand Medical
news, "We expected to find similar effects from BPS
as we have with BPA
, but not at the speed that it worked. This replacement chemical seems to be more potent and toxic.
or Bisphenol A
, a chemical used in plastic
products, was banned from baby
bottles in Canada in 2010 over concerns that it may leach into foods and cause hormone-related side effects. More manufacturers are now using BPS
as a replacement in their products and labelling them as BPA
When animal models were given bisphenol BPA
in amounts that mimicked typical human levels, their heart
function worsened, especially in females, within minutes of exposure.
These research findings are concerning, as endocrine receptors and metabolic pathways are similar in mice and humans, said Dr Pyle.
Dr Pyle added, "This study raises concerns about the safety of BPS
as a replacement for BPA
. It's particularly worrisome for people with coronary heart disease, high blood pressure, diabetes or obesity, because the effects of BPS
could increase the chance of a heart
attack or make a heart attack
more severe. If the heart
is in a precarious position, when you add a stressor you can make it worse."
The study, published recently in the journal Scientific Reports
, entailed treating mouse hearts with BPA
at levels typically seen in people. Each chemical on its own was found to depress heart
function by dampening heart
contractions causing slower blood flow. However, BPS
had a quicker impact, within five minutes of exposure.
Dr Pyle added, "Previous research has looked at the chronic effects that can happen when exposed to BPS
over days. But we are the first to show how fast BPS
can work. This is an important finding because it means you don't need to have a buildup of the chemical over time to experience its harmful effects."
is found in plastics
used for food packaging, including liners for metal cans and other containers, as well as in medical devices such as hospital intravenous lines, dental sealants, and baby
products. It is even found in skincare, toiletries and cosmetics.
Though the body gets rid of bisphenols
quickly, their ubiquitous use in so many consumer goods means that the substance persists.
Dr Pyle advocates banning the substitute chemical BPS
from such consumer products as food and beverage packaging, toys .baby products and thermal paper receipts. He also suggests consumers reduce plastic
use, including single-use plastics
Reference: Melissa Ferguson et al, Bisphenol S rapidly depresses heart function through estrogen receptor-β and decreases phospholamban phosphorylation in a sex-dependent manner, Scientific Reports (2019). DOI: 10.1038/s41598-019-52350-y