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Source: COVID-19 Questions  Aug 04, 2020  2 months ago
MUST READ! COVID-19 Questions: Can The SARS-CoV-2 Coronavirus Ultimately Also Cause Cancer?
MUST READ! COVID-19 Questions: Can The SARS-CoV-2 Coronavirus Ultimately Also Cause Cancer?
Source: COVID-19 Questions  Aug 04, 2020  2 months ago
COVID-19 Questions: Some of you might be shocked at this question and might even think that it is a stupid question but just stop for a while….we know based on proven medical studies and research that certain viral infections caused by certain viruses can in fact lead to cancer such as the following:


 
-Epstein-Barr virus (EBV)
This virus is best known for causing mononucleosis (mono). Most people in the U.S. will get EBV at some point, whether or not they actually get sick. EBV will stay in your body for life, usually not causing problems. However, EBV can sometimes trigger a type of lymphoma, cancer of the lymphatic system.
 
-Hepatitis B and C 
These viruses spread through contact with infected blood and having sex with an infected person. People with these viruses have hepatitis (inflamed liver). If the infection lasts a long time, it can permanently damage your liver, called cirrhosis. Cirrhosis can lead to liver cancer. 
 
-Human herpes virus 8 (HHV-8)
This virus is spread mostly through sexual contact. While it does not cause symptoms in most people who have it, it can cause Kaposi sarcoma, especially in people with a weakened immune system.
 
-Human immunodeficiency virus (HIV
HIV is spread through contact with infected blood and having sex with an infected person. While best known for causing AIDS, HIV infects white blood cells and weakens your immune system. That increases your risk of all kinds of disease, including cancer. HIV is linked with Kaposi sarcoma, lymphoma, head and neck cancers, and anal cancer.   
 
-Human papilloma virus (HPV)
This virus can infect your skin or mucous membranes. Sometimes it causes genital warts. You can catch HPV through sexual activity, and most sexually active people have at least one HPV infection during their lifetime. Usually your immune system will get rid of the infection, but sometimes HPV can cause cervical cancer. It also can cause some head and neck cancers, like throat cancer.
 
The list runs but these are just a few. There are even unproven hypothetical theories that say influenza infections can sometimes produce long term inflammation which can also cause cancer.

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But the reason that we at Thailand Medical News posed this question was because numerous studies on the pathogenesis of the SARS-CoV-2 coronavirus shows how the novel coronavirus is able to hijack human host cells and not just replicate but also get the human host cells to start manufacturing a variety of viral proteins while also causing disruptions to the various cellular pathways and activities of the human host cell.
  /> One are of our concerns is that it has been proven in studies that the SAR-CoV-2 affects various kinases in the human host cells. https://www.cell.com/cell/fulltext/S0092-8674(20)30811-4


This map shows how the coronavirus changes the function of kinases – cellular switches involved in most biological processes – and the proteins they control. Bouhaddou et al. Elsevier 2020CC BY-ND
 
Kinases are proteins found in every cell of our body. There are 518 human kinases, and they act as major control hubs for virtually all processes in the body. They are able to add a small marker ie a process called phosphorylation to other proteins and thus change how, if and when a phosphorylated protein can do its work.
 
For instance, if a cell is preparing to grow say to heal a cut on your finger, specific kinases will turn on and start telling proteins involved in cell growth what to do. Many cancers are caused by overactive kinases leading to uncontrolled cell growth, and drugs that slow kinases down can be highly effective at treating cancer.
 
Kinases are central players in cellular function as well as in most diseases, so researchers and pharmaceutical companies have studied them in great detail.

Considering that these kinases also play a role in cancer causing mechanisms, it is little wonder that we are concerned.
 
Furthermore there are also studies showing that SARS-CoV-2 ORF6 disrupts nucleocytoplasmic transport through interactions with the human host mRNA export factors Rae1 and Nup98. https://www.biorxiv.org/content/10.1101/2020.08.03.234559v1
 
These and certain reporter proteins again play a role in certain cancer pathways.
 
Furthermore more studies are now emerging that in term case of long-term SARS-CoV-2 infections, certain immune pathways are sort of switched off to facilitate long term infection of the virus in the human host but in small viral loads. https://www.preprints.org/manuscript/202007.0719/v1
 
Could not these long term infections also lead to cancer one way or another either through disruption of normal cellular functions and activities or through the presence of long term low inflammation?
 
We are particularly interested in various blood cancers, gastrointestinal cancers such as intestinal cancers, gastric cancers, liver cancer, pancreatic cancers, bile duct cancers and also testicular cancers as there have been some unproven claims to date which we are not going into details just yet.
 
We are in the midst of conducting a detailed research on this but truly appreciate feedback from the medical community. We are extremely pleased by the response from our previous questions where hundreds of researchers around the world had given us critical data and some even initiated new studies just to answer our questions.
 
For more on COVID-19 Questions and answers to them, keep on logging to Thailand Medical News.

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