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Source: Thailand Medical News  Jan 12, 2020  4 years, 3 months, 6 days, 20 hours, 59 minutes ago

Molecular Mechanisms Of The Wonder Drug : Metformin

Molecular Mechanisms Of The Wonder Drug : Metformin
Source: Thailand Medical News  Jan 12, 2020  4 years, 3 months, 6 days, 20 hours, 59 minutes ago
Costing less than one Thai baht per dose, metformin is cheap Type 2 diabetes drug that has been gaining recognition as a wonder drug in recent times because of numerous medical and clinical studies showing its effectives in preventing and treating certain cancers, infections, even certain neurodegenerative diseases and also immune diseases.



Metformin has its distant roots in Medieval folk medicine and has a powerful capacity to reduce body weight, fat mass, circulating glucose and prevent diabetes altogether in people at elevated risk.

Emerging research on the most widely prescribed Type 2 diabetes drug in the world arrives as a global obesity epidemic continues unabated. Obesity is the leading risk factor for Type 2 diabetes, a metabolic disorder.

While researchers have found that more than 60 percent of metformin's ability to control Type 2 diabetes is derived from lowering body weight, it has taken until now to tease out key molecular mechanisms underlying how the medication does its job.

Dr. Stephen O'Rahilly and colleagues at the University of Cambridge, are in the vanguard of scientists worldwide who have tackled a series of metformin studies in humans and laboratory animals. The team has shown how the drug causes weight loss, even among heart patients who don't have diabetes.

Besides their work, other scientists are hailing metformin as a wonder drug not only because of its effect on Type 2 diabetes, but because of its emerging prominence in cancer research and potential influence in the lungs of those diagnosed with tuberculosis.

Dr O'Rahilly, a Professor of Clinical Biochemistry and Medicine told Thailand Medical News, "Metformin was first used as a glucose-lowering drug in patients with Type 2 diabetes. In these patients, the weight loss can be quite modest, probably because when you reduce glucose in Type 2 diabetes, you stop calories being lost in the urine as sugar, and that works against the weight-reducing effects.”

Dr O'Rahilly, who is also director of the Wellcome Trust-MRC Institute of Metabolic Science-Metabolic Research Laboratories further added, "It was only when long-term studies in non-diabetic participants were undertaken that it became clear that people who actually had good compliance with metformin</