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Source: COVID Research News  Oct 08, 2020  3 years, 6 months, 1 week, 4 days, 3 hours, 24 minutes ago

COVID Research News: Swedish Researchers Discover That Liquid Gel in COVID-19 Patients' Lungs Is Hyaluronan

COVID Research News: Swedish Researchers Discover That Liquid Gel in COVID-19 Patients' Lungs Is Hyaluronan
Source: COVID Research News  Oct 08, 2020  3 years, 6 months, 1 week, 4 days, 3 hours, 24 minutes ago
COVID Research News: Swedish researchers from Umea University in a new detailed study have now established what the active agent in the jelly like substance often found in the lungs of COVID-19 patients is.


 
It was found that in most patients who had died with severe COVID-19 and respiratory failure, a jelly was formed in the lungs. The formation of the jelly in the lungs of COVID-19 patients often leads to a worsening of respiratory issues and other bodily conditions.
 
Severe COVID-19 disease is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal COVID-19, lungs at autopsy have been found to be filled with a clear liquid jelly. However, the nature of jelly has not yet been determined. The aim of the study was to demonstrate if the lungs of fatal COVID-19 contain hyaluronan (HA) as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly. Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue.
 
Stainings confirmed that hyaluronan was obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue.
 
This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2.
 
The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs.
 
The research findings were published in the Journal of Biological Chemistry https://www.jbc.org/content/early/2020/09/25/jbc.AC120.015967
 
To date there are already therapies that either slow down the body's production of this jelly or breaks down the jelly through an enzyme.
 
Dr Urban Hellman, researcher from Umeå University told Thailand medical News, “Interestingly, our findings can also explain why cortisone seems to have an effect on COVID-19."