COVID-19 Research: Interesting COVID-19 Pre-Print Non-Peer Reviewed Research Studies Worth Exploring (Vol 1)
: Thailand Medical News is starting a new weekly series of articles on various pre-print research studies that have been published on numerous servers but have yet to have bee peer-reviewed. Most will warrant further research but these are some of the selected studies that we feel need to be explored in detail further.
1. Study shows that ACE2 and TMPRSS2 receptors which are binding sites for the SARS-CoV-2 coronavirus are not expressed much in the epithelial gut linings of inflamed intestines or those suffering from IBD. https://www.biorxiv.org/content/10.1101/2020.05.21.109124v1
This is an interested study conducted by researchers from Icahn School Of Medicine, Mount Sinai and although the study focuses on the expression of the ACE2 and TMPRSS2 receptors in the guts and also the effects of medications use to treat IBD, an interesting point is that if further studies could be conducted to see as to what on a cellular level prevents these receptors from being expressed in inflamed gut tissues, then maybe a therapeutic compound could be evolved to treat COVID-19.
2. Clinical report indicates that using the drug almitrine high Improve conditions in patients experiencing hypoxia. https://www.medrxiv.org/content/10.1101/2020.05.18.20105502v1
A research by French medical experts show that administering the drug almitrine might help hypoxia patients that are experiencing pulmonary vasodilation with altered hypoxic pulmonary vasoconstriction (HPV). Besides prone positioning, this strategy may reduce the intrapulmonary shunt. This will also prevent the need for more serious interventions such as using ventilators or ECMO.
3. Research by scientists from Scripps Research Institute claim that cholesterol helps the SARS-CoV-2 to bind to the ACE2 and TMPRSS2 receptors. https://www.biorxiv.org/content/10.1101/2020.05.09.086249v2
This research is interesting and worth exploring as it shows that even lowering blood cholesterol levels are not effective as the tissues regions could be rich with the cholesterol and aid the novel coronavirus to bind to the desired receptors. Also it says that Polyunsaturated fatty acids or PUFAs such as omega 3 fatty acids or oils could help counter these effects.
4. Using Celebrex as an Adjuvant Drug To Treat COVID-19, a research by Chinese medical professionals from the Chinese Academy of Sciences in Guangzhou. https://www.medrxiv.org/content/10.1101/2020.05.05.20077610v1
This study demonstrates that Celebrex is able to inhibit the production of excessive prostaglandins E2 (PGE2) that normally trigger the cytokine storms in COVID-19 patients. The clinical trial was conducted on a group of 44 patients and deserves further research.
5. Famotidine does not act on the binding sites of S-proteins to stop virus replication; rather it works by histamine release to help COVID-19 patients.
This interesting study dispels initially clinical trials claiming that famotidine had antiviral properties. The research by Icahn Medical School, University Of North Carolina and McGill University provides interesting insights as to how instead famotidine can help COVID-19 patients.
6. Study shows that aerosol particles laden SARS-CoV-2 coronavirus can travel up to 30 meters! https://www.preprints.org/manuscript/202004.0546/v2
Now this new study from Kent University could really shake things up as it claims that aerosol particles with the virus could travel up to 30 meters and gives an example of a person in a public place (e.g. supermarket or car park) that can accumulate in the respiratory system up to 200 virus copies in 2 min time by breathing in virus laden aerosols. The study showed that wearing face mask considerably reduces the deposited load down to 2 virus copies per 2 min.
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