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Source: COVID-19 Antibodies  Oct 09, 2020  3 years, 6 months, 1 week, 3 days, 3 hours, 6 minutes ago

COVID-19 Antibodies: University Of Toronto Study Shows That SARS-CoV-2 Coronavirus Antibodies Last For Only About Three Months After Infection!

COVID-19 Antibodies: University Of Toronto Study Shows That SARS-CoV-2 Coronavirus Antibodies Last For Only About Three Months After Infection!
Source: COVID-19 Antibodies  Oct 09, 2020  3 years, 6 months, 1 week, 3 days, 3 hours, 6 minutes ago
COVID-19 Antibodies: Canadian researchers led by scientists from Temerty Faculty of Medicine at the University of Toronto and also from Lunenfeld-Tanenbaum Research Institute (LTRI) at Sinai Health-Toronto along with expers from numerous other Canadian entities and institutions have in a new study found that the SARS-CoV-2 coronavirus antibodies can last for only  about three months after a person becomes infected with the virus that causes COVID-19.


 
The study team used both saliva and blood samples from COVID-19 patients to measure and compare antibody levels for over three months post-symptom onset.
 
Although the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the antibody response in saliva and its relationship to systemic antibody levels.
 
The study team profiled by enzyme-linked immunosorbent assays (ELISAs) IgG, IgA and IgM responses to the SARS-CoV-2 spike protein (full length trimer) and its receptor-binding domain (RBD) in serum and saliva of acute and convalescent patients with laboratory-diagnosed COVID-19 ranging from 3–115 days post-symptom onset (PSO), compared to negative controls. Anti-SARS-CoV-2 antibody responses were readily detected in serum and saliva, with peak IgG levels attained by 16–30 days PSO. Longitudinal analysis revealed that anti-SARS-CoV-2 IgA and IgM antibodies rapidly decayed, while IgG antibodies remained relatively stable up to 105 days PSO in both biofluids. Lastly, IgG, IgM and to a lesser extent IgA responses to spike and RBD in the serum positively correlated with matched saliva samples. This study confirms that serum and saliva IgG antibodies to SARS-CoV-2 are maintained in the majority of COVID-19 patients for at least 3 months PSO. IgG responses in saliva may serve as a surrogate measure of systemic immunity to SARS-CoV-2 based on their correlation with serum IgG responses.
 
The study findings will have massive implications for vaccines that are currently under development or in phase 3 trials and also for antibody treatments being developed or tested